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dc.contributor.authorHeredia, Margarita
dc.contributor.authorRodríguez, Natalia
dc.contributor.authorSánchez Robledo, Virginia
dc.contributor.authorCriado, José María
dc.contributor.authorFuente, Antonio de la
dc.contributor.authorDevesa Múgica, Jesús
dc.contributor.authorDevesa Peleteiro, Pablo
dc.contributor.authorSánchez Riolobos, Adelaida
dc.date.accessioned2020-11-26T14:04:31Z
dc.date.available2020-11-26T14:04:31Z
dc.date.issued2019
dc.identifier.citationHeredia, M.; Rodríguez, N.; Sánchez Robledo, V.; Criado, J.M.; de la Fuente, A.; Devesa, J.; Devesa, P.; Sánchez Riolobos, A. Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus. Int. J. Mol. Sci. 2019, 20, 5770
dc.identifier.urihttp://hdl.handle.net/10347/23836
dc.description.abstractPreviously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (n = 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery
dc.description.sponsorshipThis research was funded by Foundation Foltra (Teo, Spain), grant number 2018-8
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGrowth hormone
dc.subjectTraumatic brain injury
dc.subjectNeural plasticity
dc.subjectNeurogenesis
dc.subjectActin
dc.subjectNestin
dc.subjectStriatum
dc.subjectThalamus
dc.titleFactors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/ijms20225770
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20225770
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1422-0067
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.description.peerreviewedSI


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
This item's license is described as
 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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