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dc.contributor.authorCosta, Clotilde
dc.contributor.authorMuinelo Romay, Laura
dc.contributor.authorCebey López, Miriam
dc.contributor.authorPereira Veiga, Tais
dc.contributor.authorMartínez Pena, Inés
dc.contributor.authorAbreu Rodríguez, Manuel
dc.contributor.authorAbalo, Alicia
dc.contributor.authorLago Lestón, Ramón
dc.contributor.authorAbuín, Carmen
dc.contributor.authorPalacios, Patricia
dc.contributor.authorCueva, Juan
dc.contributor.authorPiñeiro Cid, Roberto
dc.contributor.authorLópez López, Rafael
dc.date.accessioned2020-11-30T11:55:10Z
dc.date.available2020-11-30T11:55:10Z
dc.date.issued2020
dc.identifier.citationCosta, C.; Muinelo-Romay, L.; Cebey-López, V.; Pereira-Veiga, T.; Martínez-Pena, I.; Abreu, M.; Abalo, A.; Lago-Lestón, R.M.; Abuín, C.; Palacios, P.; Cueva, J.; Piñeiro, R.; López-López, R. Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes. Cancers 2020, 12, 1111
dc.identifier.urihttp://hdl.handle.net/10347/23864
dc.description.abstractCirculating tumor cell (CTC) enumeration has emerged as a powerful biomarker for the assessment of prognosis and the response to treatment in metastatic breast cancer (MBC). Moreover, clinical evidences show that CTC-cluster counts add prognostic information to CTC enumeration, however, their significance is not well understood, and more clinical evidences are needed. We aim to evaluate the prognostic value of longitudinally collected single CTCs and CTC-clusters in a heterogeneous real-world cohort of 54 MBC patients. Blood samples were longitudinally collected at baseline and follow up. CTC and CTC-cluster enumeration was performed using the CellSearch® system. Associations with progression-free survival (PFS) and overall survival (OS) were evaluated using Cox proportional hazards modelling. Elevated CTC counts and CTC-clusters at baseline were significantly associated with a shorter survival time. In joint analysis, patients with high CTC counts and CTC-cluster at baseline were at a higher risk of progression and death, and longitudinal analysis showed that patients with CTC-clusters had significantly shorter survival compared to patients without clusters. Moreover, patients with CTC-cluster of a larger size were at a higher risk of death. A longitudinal analysis of a real-world cohort of MBC patients indicates that CTC-clusters analysis provides additional prognostic value to single CTC enumeration, and that CTC-cluster size correlates with patient outcome
dc.description.sponsorshipThis research was supported by Roche-Chus Joint Unit (IN853B 2018/03), funded by Axencia Galega de Innovación (GAIN), Consellería de Economía, Emprego e Industria and by the Instituto de Salud Carlos III (ISCIII) and FEDER (PI13/01388). L.M.-R. is supported by Asociación Española Contra el Cáncer (AECC). I.M.-P. is funded by the Training Program for Academic Staff fellowship (FPU16/01018), from the Ministry of Education and Vocational Training, Spanish Government
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBreast cancer
dc.subjectMetastasis
dc.subjectCirculating tumor cells (CTCs)
dc.subjectCTC-clusters
dc.subjectPrognosis
dc.titleAnalysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes
dc.typejournal article
dc.identifier.doi10.3390/cancers12051111
dc.relation.publisherversionhttps://doi.org/10.3390/cancers12051111
dc.type.hasVersionVoR
dc.identifier.essn2072-6694
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
dc.description.peerreviewedSI


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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