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dc.contributor.authorMatos, Maria João Correia Pinto Carvalho de
dc.contributor.authorPérez Cruz, Fernanda
dc.contributor.authorVázquez Rodríguez, Saleta
dc.contributor.authorUriarte Villares, Eugenio
dc.contributor.authorSantana Penín, María Lourdes
dc.contributor.authorBorges, Fernanda
dc.contributor.authorOlea Azar, Claudio
dc.date.accessioned2021-01-27T09:55:20Z
dc.date.available2021-01-27T09:55:20Z
dc.date.issued2013
dc.identifier.citationBioorganic & Medicinal Chemistry, Volume 21, Issue 13, 1 July 2013, Pages 3900-3906
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10347/24337
dc.description.abstractIn the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases
dc.description.sponsorshipThe current work was supported by Mecesup (Project UCH-0601), CONICYT-Chile (Project N 24110059), Fundação para a Ciência e Tecnologia (Project PTDC/QUI-QUI/113687/2009) and personal funds from the researchers. M.J. Matos thanks Fundação para a Ciência e Tecnologia (SFRH/BD/61262/2009) Ph.D. Grant, F. Pérez-Cruz thanks CONICYT-Chile PhD. grant, Becas-Chile and Fulbright doctoral stay fellowships and S. Vazquez-Rodriguez thanks Ministerio de Educación y Ciencia (AP2008-04263) PhD. Grant
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F61262%2F2009/PT
dc.rights© 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY license
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject3-Arylcoumarins
dc.subjectHydroxyl derivatives
dc.subjectORAC-FL assays
dc.subjectESR assays
dc.subjectCV assays
dc.subjectAntioxidant capacity
dc.titleRemarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.bmc.2013.04.015
dc.relation.publisherversionhttps://doi.org/10.1016/j.bmc.2013.04.015
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY license
Except where otherwise noted, this item's license is described as  © 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY license





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