Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
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Título: | Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance |
Autor/a: | Quiñones Téllez, María del Mar Martínez Grobas, Eva Fernø, Johan Pérez Lois, Raquel Seoane, María Luisa Al-Massadi Iglesias, Omar |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Fisioloxía |
Palabras chave: | SIRT1 | SIRT6 | Energy balance | Food intake | Body weight | Adiposity | Type 2 diabetes | Obesity | |
Data: | 2021 |
Editor: | MDPI |
Cita bibliográfica: | Int. J. Mol. Sci. 2021, 22(3), 1430; https://doi.org/10.3390/ijms22031430 |
Resumo: | Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balance |
Versión do editor: | https://doi.org/10.3390/ijms22031430 |
URI: | http://hdl.handle.net/10347/24452 |
DOI: | 10.3390/ijms22031430 |
E-ISSN: | 1422-0067 |
Dereitos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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