κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/24455
Ficheiros no ítem
Metadatos do ítem
Título: | κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance |
Autor/a: | Seoane Collazo, Patricia Romero Picó, Amparo Rial Pensado, Eva Liñares Pose, Laura Estévez Salguero, María Ánxela Fernø, Johan Nogueiras Pozo, Rubén Diéguez González, Carlos López Pérez, Miguel Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Fisioloxía |
Palabras chave: | Nicotine | Kappa opioid receptor | Lateral hypothalamus | AMPK | mTOR | |
Data: | 2021 |
Editor: | MDPI |
Cita bibliográfica: | Int. J. Mol. Sci. 2021, 22(4), 1515; https://doi.org/10.3390/ijms22041515 |
Resumo: | Several studies have reported that nicotine, the main bioactive component of tobacco, exerts a marked negative energy balance. Apart from its anorectic action, nicotine also modulates energy expenditure, by regulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. These effects are mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and energy sensors, such as AMP-activated protein kinase (AMPK). In this study, we aimed to investigate the kappa opioid receptor (κOR)/dynorphin signaling in the modulation of nicotine’s effects on energy balance. We found that body weight loss after nicotine treatment is associated with a down-regulation of the κOR endogenous ligand dynorphin precursor and with a marked reduction in κOR signaling and the p70 S6 kinase/ribosomal protein S6 (S6K/rpS6) pathway in the lateral hypothalamic area (LHA). The inhibition of these pathways by nicotine was completely blunted in κOR deficient mice, after central pharmacological blockade of κOR, and in rodents where κOR was genetically knocked down specifically in the LHA. Moreover, κOR-mediated nicotine effects on body weight do not depend on orexin. These data unravel a new central regulatory pathway modulating nicotine’s effects on energy balance |
Versión do editor: | https://doi.org/10.3390/ijms22041515 |
URI: | http://hdl.handle.net/10347/24455 |
DOI: | 10.3390/ijms22041515 |
E-ISSN: | 1422-0067 |
Dereitos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
Coleccións
-
- FIS-Artigos [114]
O ítem ten asociados os seguintes ficheiros de licenza: