Mostrar o rexistro simple do ítem

dc.contributor.authorGuardado Yordi, Estela
dc.contributor.authorMatos, Maria João Correia Pinto Carvalho de
dc.contributor.authorUriarte Villares, Eugenio
dc.contributor.authorPérez Martínez, Amaury
dc.contributor.authorSantana Penín, María Lourdes
dc.contributor.authorMolina, Enrique
dc.date.accessioned2021-04-12T08:01:35Z
dc.date.available2021-04-12T08:01:35Z
dc.date.issued2016
dc.identifier.citationGuardado Yordi, E., Matos, M.J., Uriarte, E., Pérez Martínez, A., Santana, L. & Molina, E. (2016). In silico study of new structural alerts of agents clastogenic. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin. (Ed.), Proceedings ECSOC-20: The 20Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2016. MDPI. doi: 10.3390/ecsoc-20-e021
dc.identifier.isbn978-3-03842-192-4
dc.identifier.urihttp://hdl.handle.net/10347/25745
dc.description.abstractNatural polyphenols and their derivatives from diet have been reported by their pro-oxidant and clastogenic activities. In an aim of elucidating structural alerts for this genotoxicity endpoint, a QSTR study was conducted under the TOPS-MODE approach. It was possible to establish structural alerts from the DNA oxidative damage as an endpoint of clastogenicity at optimum leaders with high probability of being clastogenic. Some important fragments to obviate this activity were also identified. The results constitute a reference system for designing new food or pharmaceutical matrices as an alternative to the experimental toxicology
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesElectronic Conference on Synthetic Organic Chemistry;20
dc.rights© 2016 by MDPI, Basel, Switzerland. Open Access
dc.subjectStructural alerts
dc.subjectPro-oxidant activity
dc.subjectClastogenicity
dc.subjectFlavonoids
dc.subjectTOPS-MODE approach
dc.titleIn silico study of new structural alerts of agents clastogenic
dc.typebook part
dc.identifier.doi10.3390/ecsoc-20-e021
dc.relation.publisherversionhttps://doi.org/10.3390/ecsoc-20-e021
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica


Ficheiros no ítem

application/pdf
Nome: 2016_ecsoc20_guardado_silico.pdf
Tamaño: 318.3 Kb
Formato: PDF


Thumbnail

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem






Recolectores:Enlaces de interese:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contacto | Suxestións