Interest of 3-arylcoumarins as xanthine oxidase inhibitors
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| Title: | Interest of 3-arylcoumarins as xanthine oxidase inhibitors |
| Author: | Matos, Maria João Correia Pinto Carvalho de Borges, Fernanda Santana Penín, María Lourdes Uriarte Villares, Eugenio Medda, Rosaria Pintus, Francesca Caboni, Martina Era, Benedetta Fais, Antonella Petrillo, Amalia di |
| Affiliation: | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | 3-Arylcoumarins | Condensation reaction | Cross-coupling reaction | Xanthine oxidase inhibitors | Gout | |
| Date of Issue: | 2015 |
| Publisher: | MDPI |
| Citation: | Matos, M.J., Borges, F., Santanta, L., Uriarte, E., Medda, R., Pintus, F., Caboni, M., Era, B. Fais, A. & Di Petrillo, A. (2015). Interest of 3-arylcoumarins as xanthine oxidase inhibitors. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin, Proceedings ECSOC-19: The 19Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2015. MDPI. doi: 10.3390/ecsoc-19-b002 |
| Series/Report no.: | Electronic Conference on Synthetic Organic Chemistry;19 |
| Abstract: | In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout |
| Description: | The 19th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry |
| Publisher version: | https://doi.org/10.3390/ecsoc-19-b002 |
| URI: | http://hdl.handle.net/10347/25880 |
| DOI: | 10.3390/ecsoc-19-b002 |
| ISBN: | 978-3-03842-145-0 |
| Rights: | © 2016 by MDPI, Basel, Switzerland. Open Access |
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