Transgenerational inheritance of chemical-induced signature: A case study with simvastatin
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Title: | Transgenerational inheritance of chemical-induced signature: A case study with simvastatin |
Author: | Neuparth, Teresa Machado, André M. Montes Goyanes, Rosa María Rodil Rodríguez, María del Rosario Barros, Susana Alves, Nélson Ruivo, Raquel Castro, Luis Filipe Quintana Álvarez, José Benito Santos, Miguel Machado |
Affiliation: | Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias |
Subject: | Simvastatin | Transgenerational effects | Reproduction | Transcriptomic | Epigenetics | Regulatory agencies | |
Date of Issue: | 2020 |
Publisher: | Elsevier |
Citation: | Environment International 144 (2020) 106020 |
Abstract: | The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and adverse outcomes. We demonstrate here reproductive multi and transgenerational effects, at environmentally relevant levels, of one of the most prescribed human pharmaceuticals, simvastatin, in a keystone species, the amphipod Gammarus locusta. The transgenerational findings has major implications for hazard and risk assessment of pharmaceuticals and other contaminants of emerging concern given that transgenerational effects of environmental chemicals are not addressed in current hazard and risk assessment schemes. Considering that the mevalonate synthesis, one of the key metabolic pathways targeted by simvastatin, is highly conserved among metazoans, these results may also shed light on the potential transgenerational effects of simvastatin on other animals, including humans. |
Publisher version: | https://doi.org/10.1016/j.envint.2020.106020 |
URI: | http://hdl.handle.net/10347/26080 |
DOI: | 10.1016/j.envint.2020.106020 |
ISSN: | 0160-4120 |
Rights: | © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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