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dc.contributor.authorGutiérrez Lovera, Carlha Rodmar
dc.contributor.authorVázquez Ríos, Abi Judit
dc.contributor.authorGuerra Varela, Jorge
dc.contributor.authorSánchez Piñón, Laura Elena
dc.contributor.authorFuente Freire, María de la
dc.date.accessioned2021-05-04T12:30:45Z
dc.date.available2021-05-04T12:30:45Z
dc.date.issued2017
dc.identifier.citationGenes 2017, 8(12), 349; https://doi.org/10.3390/genes8120349
dc.identifier.urihttp://hdl.handle.net/10347/26107
dc.description.abstractIn the last few decades, the field of nanomedicine applied to cancer has revolutionized cancer treatment: several nanoformulations have already reached the market and are routinely being used in the clinical practice. In the case of genetic nanomedicines, i.e., designed to deliver gene therapies to cancer cells for therapeutic purposes, advances have been less impressive. This is because of the many barriers that limit the access of the therapeutic nucleic acids to their target site, and the lack of models that would allow for an improvement in the understanding of how nanocarriers can be tailored to overcome them. Zebrafish has important advantages as a model species for the study of anticancer therapies, and have a lot to offer regarding the rational development of efficient delivery of genetic nanomedicines, and hence increasing the chances of their successful translation. This review aims to provide an overview of the recent advances in the development of genetic anticancer nanomedicines, and of the zebrafish models that stand as promising tools to shed light on their mechanisms of action and overall potential in oncology
dc.description.sponsorshipThis work was supported by the Xunta de Galicia, Spain (Competitive Reference Groups, GRC2014/010), the Carlos III Health Institute/FEDER (PI15/00828), and the Spanish Ministry of Education, Culture and Sport (FPU15/06595)
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNanomedicines
dc.subjectCancer
dc.subjectGene therapies
dc.subjectZebrafish
dc.subjectTranslation
dc.titleThe Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines
dc.typejournal article
dc.identifier.doi10.3390/genes8120349
dc.relation.publisherversionhttps://doi.org/10.3390/genes8120349
dc.type.hasVersionVoR
dc.identifier.essn2073-4425
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física
dc.description.peerreviewedSI


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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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