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dc.contributor.authorSilva Álvarez, Sabela da
dc.contributor.authorGuerra Varela, Jorge
dc.contributor.authorSobrido Cameán, Daniel
dc.contributor.authorQuelle Regaldie, Ana
dc.contributor.authorBarreiro Iglesias, Antón
dc.contributor.authorSánchez Piñón, Laura Elena
dc.contributor.authorCollado, Manuel
dc.date.accessioned2021-05-04T13:24:54Z
dc.date.available2021-05-04T13:24:54Z
dc.date.issued2020
dc.identifier.citationDa Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M. Developmentally-programmed cellular senescence is conserved and widespread in zebrafish. Aging (Albany NY). 2020; 12:17895-17901. https://doi.org/10.18632/aging.103968
dc.identifier.urihttp://hdl.handle.net/10347/26112
dc.description.abstractCellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse embryo development at particular structures during specific periods of time. This programmed cell senescence has been proposed to serve developmental and morphogenetic functions and to potentially represent an evolutionary origin of senescence. Cellular senescence has also been described to take place during bird (chick and quail) and amphibian (xenopus and axoltl) development. Fish however, have been described to show a very narrow and restricted pattern of developmental cell senescence. Here we carried out a detailed characterization of senescence during zebrafish development and found it to be conserved and widespread. Apart from yolk and cloaca, previously described structures, we also identified senescence in the developing central nervous system, intestine, liver, pronephric ducts, and crystalline. Interestingly, senescence at these developing structures disappeared upon treatment with senolytic compound ABT-263, supporting their senescent identity and opening the possibility of studying the contribution of this process to development. In summary, our findings extend the description of developmentally-programmed cell senescence to lower vertebrates contributing to the notion of the relevance of this process for embryo development
dc.description.sponsorshipFunding at the laboratory of M.C. is provided by the Ministerio de Ciencia, Innovación y Universidades, Fondos Europeos de Desarrollo Regional (FEDER) (RTI2018-095818-B-100). Work in the laboratory of A.B.-I. was funded by grants from the Xunta de Galicia (2016-PG008) and the crowdfunding platform Precipita (FECYT; 2017-CP081). Funding at laboratory of L.S. is provided by Xunta de Galicia (ED431C2018/28)
dc.language.isoeng
dc.publisherImpact Journals
dc.rightsCopyright: © 2020 Da Silva-Álvarez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectCellular senescence
dc.subjectDevelopment
dc.subjectZebrafish
dc.titleDevelopmentally-programmed cellular senescence is conserved and widespread in zebrafish
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.18632/aging.103968
dc.relation.publisherversionhttps://doi.org/10.18632/aging.103968
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1945-4589
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioloxía Funcional
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física
dc.description.peerreviewedSI


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Copyright: © 2020 Da Silva-Álvarez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Except where otherwise noted, this item's license is described as  Copyright: © 2020 Da Silva-Álvarez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited





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