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dc.contributor.authorRoel Sánchez, María
dc.contributor.authorRubiolo Gaytán, Juan Andrés
dc.contributor.authorGuerra Varela, Jorge
dc.contributor.authorSilva, Siguara B. L.
dc.contributor.authorThomas, Olivier P.
dc.contributor.authorCabezas Sáinz, Pablo
dc.contributor.authorSánchez Piñón, Laura Elena
dc.contributor.authorLópez López, Rafael
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2021-05-04T13:56:16Z
dc.date.available2021-05-04T13:56:16Z
dc.date.issued2016
dc.identifier.citationRoel M., Rubiolo J. A., Guerra-Varela J., Silva S. B. L., Thomas O. P., Cabezas-Sainz P., Sánchez L., López R., Botana L. M. Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model. Oncotarget. 2016; 7: 83071-83087. Retrieved from https://www.oncotarget.com/article/13068/text/
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/10347/26114
dc.description.abstractThe marine environment constitutes an extraordinary resource for the discovery of new therapeutic agents. In the present manuscript we studied the effect of 3 different sponge derived guanidine alkaloids, crambescidine-816, -830, and -800. We show that these compounds strongly inhibit tumor cell proliferation by down-regulating cyclin-dependent kinases 2/6 and cyclins D/A expression while up-regulating the cell cyclin-dependent kinase inhibitors -2A, -2D and -1A. We also show that these guanidine compounds disrupt tumor cell adhesion and cytoskeletal integrity promoting the activation of the intrinsic apoptotic signaling, resulting in loss of mitochondrial membrane potential and concomitant caspase-3 cleavage and activation. The crambescidin 816 anti-tumor effect was fnally assayed in a zebrafish xenotransplantation model confirming its potent antitumor activity against colorectal carcinoma in vivo. Considering these results crambescidins could represent promising natural anticancer agents and therapeutic tools
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofunded-grants. From CDTI and Technological Funds, supported by Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R, and Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD. From the European Union’s Seventh Framework Programme managed by REA – Research Executive Agency (FP7/2007-2013) under grant agreement 312184 PHARMASEA. M.R.S. is an I2C predoctoral fellow. From CAPES Foundation, Brazil (scholarship process: BEX 10184-13-9)
dc.language.isoeng
dc.publisherImpact Journals
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/312184
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS
dc.rights© The Author(s) 2016. Open Access. This article is licensed under the Creative Commons Attribution 3.0 License (CC BY 3.0)
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.titleMarine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.18632/oncotarget.13068
dc.relation.publisherversionhttps://doi.org/10.18632/oncotarget.13068
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física
dc.description.peerreviewedSI


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© The Author(s) 2016. Open Access. This article is licensed under the Creative Commons Attribution 3.0 License (CC BY 3.0)
Except where otherwise noted, this item's license is described as  © The Author(s) 2016. Open Access. This article is licensed under the Creative Commons Attribution 3.0 License (CC BY 3.0)





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