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dc.contributor.author | Cid Fernández, Susana |
dc.contributor.author | Lindín Novo, Mónica |
dc.contributor.author | Díaz Fernández, Fernando |
dc.date.accessioned | 2021-05-10T08:28:19Z |
dc.date.available | 2021-05-10T08:28:19Z |
dc.date.issued | 2021 |
dc.identifier.citation | Neurobiology of Learning and Memory, 182 (2021), 107450 |
dc.identifier.issn | 1074-7427 |
dc.identifier.uri | http://hdl.handle.net/10347/26158 |
dc.description.abstract | In the preclinical stage of the Alzheimer’s disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state |
dc.description.sponsorship | This study was supported by grants from the Spanish Government, Ministerio de Economía y Competitividad (PSI2014-55316-C3-3-R; PSI2017-89389-C2-2-R), with FEDER Funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC); Ref: ED431-2017/27, with FEDER funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Programa de axudas de apoio á etapa de formación posdoutoral (Xunta de Galicia, 2016); Ref: ED481B2016/078-0 |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject | Event-related potentials (ERPs) |
dc.subject | Stimulus evaluation |
dc.subject | Response inhibition |
dc.subject | Subjective memory complaints (SMCs) |
dc.subject | Alzheimer’s Disease (AD) |
dc.title | Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing |
dc.type | journal article |
dc.identifier.doi | 10.1016/j.nlm.2021.107450 |
dc.relation.publisherversion | https://doi.org/10.1016/j.nlm.2021.107450 |
dc.type.hasVersion | VoR |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2014-55316-C3-3-R/ES/EVOLUCION DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES PSICOFISIOLOGICOS Y DE NEUROIMAGEN FUNCIONAL |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PSI2017-89389-C2-2-R/ES/ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL DCL Y EA CON MARCADORES NEUROCOGNITIVOS. EFECTOS DE LA EST ELECTRICA T. EN UN PROGRAMA INTEGRADO DE EST. COGNITIVA |
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