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dc.contributor.authorCid Fernández, Susana
dc.contributor.authorLindín Novo, Mónica
dc.contributor.authorDíaz Fernández, Fernando
dc.date.accessioned2021-05-10T08:28:19Z
dc.date.available2021-05-10T08:28:19Z
dc.date.issued2021
dc.identifier.citationNeurobiology of Learning and Memory, 182 (2021), 107450
dc.identifier.issn1074-7427
dc.identifier.urihttp://hdl.handle.net/10347/26158
dc.description.abstractIn the preclinical stage of the Alzheimer’s disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state
dc.description.sponsorshipThis study was supported by grants from the Spanish Government, Ministerio de Economía y Competitividad (PSI2014-55316-C3-3-R; PSI2017-89389-C2-2-R), with FEDER Funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC); Ref: ED431-2017/27, with FEDER funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Programa de axudas de apoio á etapa de formación posdoutoral (Xunta de Galicia, 2016); Ref: ED481B2016/078-0
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2014-55316-C3-3-R/ES/EVOLUCION DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES PSICOFISIOLOGICOS Y DE NEUROIMAGEN FUNCIONAL
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PSI2017-89389-C2-2-R/ES/ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL DCL Y EA CON MARCADORES NEUROCOGNITIVOS. EFECTOS DE LA EST ELECTRICA T. EN UN PROGRAMA INTEGRADO DE EST. COGNITIVA
dc.rights© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEvent-related potentials (ERPs)
dc.subjectStimulus evaluation
dc.subjectResponse inhibition
dc.subjectSubjective memory complaints (SMCs)
dc.subjectAlzheimer’s Disease (AD)
dc.titleEvent-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.nlm.2021.107450
dc.relation.publisherversionhttps://doi.org/10.1016/j.nlm.2021.107450
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía
dc.description.peerreviewedSI


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© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Except where otherwise noted, this item's license is described as  © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)





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