In Vitro Anti-Biofilm and Antibacterial Properties of Streptococcus downii sp. nov.
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Título: | In Vitro Anti-Biofilm and Antibacterial Properties of Streptococcus downii sp. nov. |
Autor/a: | Cuenca, Maigualida Sánchez, María del Carmen Diz Dios, Pedro Martínez Lamas, Lucía Álvarez, Maximiliano Limeres Posse, Jacobo Sanz, Mariano Herrera, David |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
Palabras chave: | Oral biofilm | Streptococcus downii sp. nov. | Caries | Streptococcus mutans | Periodontal diseases | Aggregatibacter actinomycetemcomitans | |
Data: | 2021 |
Editor: | MDPI |
Cita bibliográfica: | Microorganisms 2021, 9(2), 450; https://doi.org/10.3390/microorganisms9020450 |
Resumo: | The aim of this study was to evaluate the potential anti-biofilm and antibacterial activities of Streptococcus downii sp. nov. To test anti-biofilm properties, Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans were grown in a biofilm model in the presence or not of S. downii sp. nov. for up to 120 h. For the potential antibacterial activity, 24 h-biofilms were exposed to S. downii sp. nov for 24 and 48 h. Biofilms structures and bacterial viability were studied by microscopy, and the effect in bacterial load by quantitative polymerase chain reaction. A generalized linear model was constructed, and results were considered as statistically significant at p < 0.05. The presence of S. downii sp. nov. during biofilm development did not affect the structure of the community, but an anti-biofilm effect against S. mutans was observed (p < 0.001, after 96 and 120 h). For antibacterial activity, after 24 h of exposure to S. downii sp. nov., counts of S. mutans (p = 0.019) and A. actinomycetemcomitans (p = 0.020) were significantly reduced in well-structured biofilms. Although moderate, anti-biofilm and antibacterial activities of S. downii sp. nov. against oral bacteria, including some periodontal pathogens, were demonstrated in an in vitro biofilm model |
Versión do editor: | https://doi.org/10.3390/microorganisms9020450 |
URI: | http://hdl.handle.net/10347/26215 |
DOI: | 10.3390/microorganisms9020450 |
E-ISSN: | 2076-2607 |
Dereitos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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