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dc.contributor.authorMondelo García, Cristina
dc.contributor.authorBandín Vilar, Enrique
dc.contributor.authorGarcía Quintanilla, Laura
dc.contributor.authorCastro Balado, Ana
dc.contributor.authordel Amo, Eva María
dc.contributor.authorGil Martínez, María
dc.contributor.authorBlanco Teijeiro, María José
dc.contributor.authorGonzález Barcia, Luis Miguel
dc.contributor.authorZarra Ferro, Irene
dc.contributor.authorFernández Ferreiro, Anxo
dc.contributor.authorOtero Espinar, Francisco Javier
dc.date.accessioned2021-05-19T11:34:11Z
dc.date.available2021-05-19T11:34:11Z
dc.date.issued2021
dc.identifier.citationMondelo-García, C., Bandín-Vilar, E., García-Quintanilla, L., Castro-Balado, A., del Amo, E.M., Gil-Martínez, M., Blanco-Teijeiro, M.J., González-Barcia, M., Zarra-Ferro, I., Fernández-Ferreiro, A. and Otero-Espinar, F.J. (2021), Current Situation and Challenges in Vitreous Substitutes. Macromol. Biosci. 2100066. https://doi.org/10.1002/mabi.202100066
dc.identifier.urihttp://hdl.handle.net/10347/26224
dc.description.abstractVitreo-retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo-retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6, C2F6, C3F8) and liquids (perfluorocarbon liquids, silicone oils, and heavy silicone oils). There are specific advantages and drawbacks to each of these, which determine their clinical indications. However, developing the ideal biomaterial for vitreous substitution continues to be one of the most important challenges in ophthalmology, and a multidisciplinary approach is required. In this sense, recent research has focused on the development of biocompatible, biodegradable, and injectable hydrogels (natural, synthetic, and smart), which also act as medium and long-term internal tamponade agents. This comprehensive review aims to cover the main characteristics and indications for use of the extensive range of vitreous substitutes that are currently used in clinical practice, before going on to describe the hydrogels that have been developed recently and which have emerged as promising biomaterials for vitreous substitution
dc.description.sponsorshipC.M.-G., E.B.-V., L.G.-Q., and A.F.-F. are grateful to the Carlos III Health Institute for financing the CM18/00090, CM20/00135, CM20/00024, and JR18/00014 personnel contracts. This work was partially supported by the following projects of Carlos III Health Institute (PI17/00940 and PI20/00719)
dc.language.isoeng
dc.publisherWiley
dc.rights© 2021 The Authors. Macromolecular Bioscience published by Wiley‐VCH GmbH This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBiomaterials
dc.subjectHydrogels
dc.subjectPerfluorocarbon liquids
dc.subjectSilicone oils
dc.subjectVitreous substitution
dc.titleCurrent Situation and Challenges in Vitreous Substitutes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/mabi.202100066
dc.relation.publisherversionhttps://doi.org/10.1002/mabi.202100066
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1616-5195
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.description.peerreviewedSI


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© 2021 The Authors. Macromolecular Bioscience published by Wiley‐VCH GmbH  This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
Except where otherwise noted, this item's license is described as  © 2021 The Authors. Macromolecular Bioscience published by Wiley‐VCH GmbH This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes





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