Asymmetry in Drug Permeability through the Cornea
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http://hdl.handle.net/10347/26264
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Título: | Asymmetry in Drug Permeability through the Cornea |
Autor/a: | Toffoletto, Nadia Chauhan, Anuj Álvarez Lorenzo, Carmen Isabel Saramago, Benilde Serro, Ana Paula |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Palabras chave: | Cornea | Drug permeability | Drug accumulation | Bromfenac sodium | Dexamethasone sodium | |
Data: | 2021 |
Editor: | MDPI |
Cita bibliográfica: | Pharmaceutics 2021, 13(5), 694; https://doi.org/10.3390/pharmaceutics13050694 |
Resumo: | The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitutes a more meaningful parameter when dealing with intraocular drug-delivery systems (i.e., drug-loaded intraocular lenses, intraocular implants or injections). Herein, the permeability coefficients of two commonly administered anti-inflammatory drugs (i.e., bromfenac sodium and dexamethasone sodium) were determined ex vivo using Franz diffusion cells and porcine corneas in both inward and outward configurations. A significantly higher drug accumulation in the cornea was detected in the outward direction, which is consistent with the different characteristics of the corneal layers. Coherently, a higher permeability coefficient was obtained for bromfenac sodium in the outward direction, but no differences were detected for dexamethasone sodium in the two directions. Drug accumulation in the cornea can prolong the therapeutic effect of intraocular drug-release system |
Versión do editor: | https://doi.org/10.3390/pharmaceutics13050694 |
URI: | http://hdl.handle.net/10347/26264 |
DOI: | 10.3390/pharmaceutics13050694 |
E-ISSN: | 1999-4923 |
Dereitos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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