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dc.contributor.advisorLópez López, Rafael
dc.contributor.advisorde la Fuente Freire, María
dc.contributor.advisorDíaz Lagares, Ángel
dc.contributor.authorRuiz Bañobre, Juan
dc.date.accessioned2021-06-02T07:01:13Z
dc.date.available2021-06-02T07:01:13Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10347/26358
dc.description.abstractPrecision oncology is a rapidly evolving field in many different aspects. Taking this in mind and considering the central role of biomarkers in precision oncology, this thesis affords various important aspects regarding predictive and prognostic biomarkers in two important clinical scenarios. First, this thesis presents a systematic and comprehensive review on metastatic colorectal cancer that summarizes the most relevant milestones achieved in the field of predictive biomarkers to various treatments; analyzes and discusses methodological aspects, current trends, and future directions in this exciting area. Second, because of the lack of biomarkers in the context of mucinous colorectal cancer, this thesis affords the role of microRNAs from a biological and prognostic viewpoint in this specific colorectal cancer subtype. Lastly, this thesis presents a multicenter retrospective study in metastatic urothelial carcinoma patients, which investigates the safety and efficacy of immunotherapy, and explores pretreatment factors influencing therapeutic outcomes in daily clinical practice.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPrecision oncology
dc.subjectbiomarker
dc.subjectcolorectal cancer
dc.subjecturothelial carcinoma
dc.subjectimmunotherapy
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3205 Medicina interna::320503 Gastroenterología
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3213 Cirugía::321316 Urología
dc.titleDeciphering the importance of biomarkers in colorectal and urothelial cancers in the era of precision oncology
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina


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