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dc.contributor.advisorRodríguez Osorio, Carlos
dc.contributor.advisorVences Lorenzo, Ana
dc.contributor.authorSuleiman Salameh Abushattal, Saqr
dc.date.accessioned2021-06-23T11:13:03Z
dc.date.available2021-06-23T11:13:03Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10347/26498
dc.description.abstractThe two subspecies of Photobacterium damselae, namely subsp. damselae and subsp. piscicida, are pathogenic for diverse fish species of financial importance in marine aquaculture. In the present thesis we have characterized the variable genome in these two subspecies, which proved to be highly diverse. We have demonstrated that horizontal gene transfer has played a major role in the acquisition of the ability to metabolize sucrose, and in antimicrobial resistance in the subspecies damselae. Notably, this study has unveiled the existence of a novel, highly unstable virulence plasmid, encoding a Type III secretion system (T3SS) that is highly prevalent in the subspecies piscicida, and which constitutes a new virulence factor in this pathogen.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPhotobacterium damselae
dc.subjectplasmid
dc.subjectantimicrobial resistance
dc.subjectvirulence
dc.subjectaquaculture
dc.subjectbacteria
dc.subjectT3SS
dc.subjectsucrose
dc.subject.classificationMaterias::Investigación::24 Ciencias de la vida::2415 Biología molecular::241501 Biología molecular de microorganismos
dc.titleStudy of the variable genome of Photobacterium damselae: acquisition of new metabolic traits, antimicrobial resistance and a novel virulence plasmid
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Programa de Doutoramento en Avances en Bioloxía Microbiana e Parasitaria


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