Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
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http://hdl.handle.net/10347/26592
Título: | Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
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Autor/a: | Gutiérrez González, Alejandro
Destito, Paolo
Rodríguez Couceiro, José
Pérez González, Cibrán
López García, Fernando
Mascareñas Cid, José Luis
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Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica
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Palabras chave: | Biocompatible reactions | Bioorthogonal reactions | Click chemistry | Ruthenium | Thioalkynes | |
Data: | 2021
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Editor: | Wiley
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Cita bibliográfica: | A. Gutiérrez-González, P. Destito, J. R. Couceiro, C. Pérez-González, F. López, J. L. Mascareñas, Angew. Chem. Int. Ed. 2021, 60, 16059
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Resumo: | Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal |
Versión do editor: | https://doi.org/10.1002/anie.202103645 |
URI: | http://hdl.handle.net/10347/26592
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DOI: | 10.1002/anie.202103645 |
ISSN: | 1433-7851
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E-ISSN: | 1521-3773
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Dereitos: | © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited Atribución 4.0 Internacional
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