A tese consistiu no deseño e desenvolvemento de novas formas de administración ocular de fármacos antivirais e antioxidantes. En particular, a tese centrouse no deseño de micelas poliméricas para a administración de ...

The development of siRNA-based therapies for the treatment of severe ocular diseases is being proposed as a promising therapeutic option for the treatment of severe ocular diseases. Unfortunately, the capacity of siRNA ...

The main goal of this thesis has been the generation of knowledge towards the advancement of the oral administration of peptides. The specific objective has been to study how the composition and surface properties of ...

La extrusión por fusión (EF) es una técnica que, ampliamente utilizada en la industria de plásticos y alimentaria, está recibiendo, en el ámbito farmacéutico, una atención creciente en los últimos años. A grandes rasgos, ...

Nanotechnologies with the ability to modulate the immune system can be exploited to develop new advanced therapies. The first part of this thesis describes a potential HIV vaccine candidate consisting of nanoparticles ...

This thesis project covers the design, development and in vivo evaluation of a novel self-assembled injectable biodegradable drug delivery system (DDS). The system is composed of in situ hydrogel combined with nanocapsules ...

The main goal of this thesis is the development of polymer-based nanosystems for antigen delivery to the immune system. To evaluate the influence of the physicochemical characteristics of the nanosystems in their biodistribution ...

The main objective of this work has been the design of a new polysaccharide functionalised nanosystem as a non-viral microRNA vector for the treatment of liver metastasis from colorectal cancer. For this purpose, we modified ...

The main goal of this thesis has been the engineering of innovative nanosystems of application in the treatment and molecular diagnosis of colorectal cancer. Sphingomyelin nanoemulsions (SNs) were selected for this ...

Nanotechnology offers the possibility of enhancing the performance of immunomodulatory molecules by facilitating their transport across biological barriers and targeting them to the immune system. Considering this promising ...