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dc.contributor.author | Pérez-Sayáns García, Mario |
dc.contributor.author | Chamorro Petronacci, Cintia Micaela |
dc.contributor.author | Baltazar, Fatima |
dc.contributor.author | Pires, Fábio Ramoa |
dc.contributor.author | Ínsua Brandariz, Ángel |
dc.contributor.author | Suárez Quintanilla, Juan Antonio |
dc.contributor.author | Suárez Peñaranda, José Manuel |
dc.date.accessioned | 2021-08-04T08:52:10Z |
dc.date.available | 2021-08-04T08:52:10Z |
dc.date.issued | 2021 |
dc.identifier.citation | Diagnostics 2021, 11(4), 583; https://doi.org/10.3390/diagnostics11040583 |
dc.identifier.uri | http://hdl.handle.net/10347/26689 |
dc.description.abstract | Background: The aim was to investigate the clinical significance of nestin immunohistochemical expression in head and neck area lesions and to study its role in patient survival and recurrence. Methods: 39 (44.3%) nasosinus, 37 (42%) major salivary gland (6 submandibular and 31 parotid) and 12 (13.6%) oral cavity lesions of paraffin-embedded samples were retrospectively included. Results: The expression was categorized into grades, negative for 55 (62.5%) cases, grade 1 in 10 cases (11.4%), grade 2 in 12 cases (13.6%), and grade 3 in 11 cases (12.5%); 100% of pleomorphic adenomas were positive for nestin with grade 3 intensity, 100% of polyps and inverted papillomas were negative (p < 0.001). The lowest estimate of disease-free-survival (DFS) was for grade 1 expression, with 50 months, confidence interval (CI): 95% 13.3–23.9 months and the highest for grade 3 expression, 167.9 months (CI: 95% 32.1–105 months; Log-Rank = 14.846, p = 0.002). ROC (receiver operating characteristic) curves revealed that the positivity for nestin (+/−) in relation to malignancy, presented a sensitivity of 50.98%, a specificity of 81.08%, with an area under the curve of 0.667 (p = 0.009). Conclusions: Nestin could be a useful marker to detect the presence of stem cells in head and neck tumors that have a role in tumor initiation and progression |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) |
dc.rights | Atribución 4.0 Internacional |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject | Head and neck neoplasms |
dc.subject | Nestin |
dc.subject | Immunohistochemistry |
dc.subject | Recurrence |
dc.title | Nestin Expression Is Associated with Relapses in Head and Neck Lesions |
dc.type | journal article |
dc.identifier.doi | 10.3390/diagnostics11040583 |
dc.relation.publisherversion | https://doi.org/10.3390/diagnostics11040583 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 2075-4418 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
dc.description.peerreviewed | SI |
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