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dc.contributor.authorPérez-Sayáns García, Mario
dc.contributor.authorChamorro Petronacci, Cintia Micaela
dc.contributor.authorBaltazar, Fatima
dc.contributor.authorPires, Fábio Ramoa
dc.contributor.authorÍnsua Brandariz, Ángel
dc.contributor.authorSuárez Quintanilla, Juan Antonio
dc.contributor.authorSuárez Peñaranda, José Manuel
dc.date.accessioned2021-08-04T08:52:10Z
dc.date.available2021-08-04T08:52:10Z
dc.date.issued2021
dc.identifier.citationDiagnostics 2021, 11(4), 583; https://doi.org/10.3390/diagnostics11040583
dc.identifier.urihttp://hdl.handle.net/10347/26689
dc.description.abstractBackground: The aim was to investigate the clinical significance of nestin immunohistochemical expression in head and neck area lesions and to study its role in patient survival and recurrence. Methods: 39 (44.3%) nasosinus, 37 (42%) major salivary gland (6 submandibular and 31 parotid) and 12 (13.6%) oral cavity lesions of paraffin-embedded samples were retrospectively included. Results: The expression was categorized into grades, negative for 55 (62.5%) cases, grade 1 in 10 cases (11.4%), grade 2 in 12 cases (13.6%), and grade 3 in 11 cases (12.5%); 100% of pleomorphic adenomas were positive for nestin with grade 3 intensity, 100% of polyps and inverted papillomas were negative (p < 0.001). The lowest estimate of disease-free-survival (DFS) was for grade 1 expression, with 50 months, confidence interval (CI): 95% 13.3–23.9 months and the highest for grade 3 expression, 167.9 months (CI: 95% 32.1–105 months; Log-Rank = 14.846, p = 0.002). ROC (receiver operating characteristic) curves revealed that the positivity for nestin (+/−) in relation to malignancy, presented a sensitivity of 50.98%, a specificity of 81.08%, with an area under the curve of 0.667 (p = 0.009). Conclusions: Nestin could be a useful marker to detect the presence of stem cells in head and neck tumors that have a role in tumor initiation and progression
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHead and neck neoplasms
dc.subjectNestin
dc.subjectImmunohistochemistry
dc.subjectRecurrence
dc.titleNestin Expression Is Associated with Relapses in Head and Neck Lesions
dc.typejournal article
dc.identifier.doi10.3390/diagnostics11040583
dc.relation.publisherversionhttps://doi.org/10.3390/diagnostics11040583
dc.type.hasVersionVoR
dc.identifier.essn2075-4418
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
dc.description.peerreviewedSI


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)





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