Mostrar o rexistro simple do ítem
dc.contributor.author | Rapado González, Óscar |
dc.contributor.author | Martínez Reglero, Cristina |
dc.contributor.author | Salgado Barreiro, Ángel |
dc.contributor.author | Muinelo Romay, Laura |
dc.contributor.author | López López, Rafael |
dc.contributor.author | Muinelo Lorenzo, Juan |
dc.contributor.author | López López, Rafael |
dc.contributor.author | Díaz Lagares, Ángel |
dc.contributor.author | Suárez Cunqueiro, María Mercedes |
dc.date.accessioned | 2021-08-06T13:15:38Z |
dc.date.available | 2021-08-06T13:15:38Z |
dc.date.issued | 2021 |
dc.identifier.citation | J. Pers. Med. 2021, 11(6), 568; https://doi.org/10.3390/jpm11060568 |
dc.identifier.uri | http://hdl.handle.net/10347/26711 |
dc.description.abstract | DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis |
dc.description.sponsorship | This work was co-funded by the Instituto de Salud Carlos III (ISCIII) (PI20/01449) and the European Regional Development Fund (FEDER). A.D.-L. is funded by a “Juan Rodés” contract from ISCIII (JR17/00016). L.M.-R. is funded by a “Miguel Servet” contract from ISCIII (CP20/00129) |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) |
dc.rights | Atribución 4.0 Internacional |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject | DNA methylation |
dc.subject | Epigenetics |
dc.subject | Head and neck cancer |
dc.subject | Saliva |
dc.subject | Biomarkers |
dc.subject | Liquid biopsy |
dc.subject | Meta-analysis |
dc.title | Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis |
dc.type | journal article |
dc.identifier.doi | 10.3390/jpm11060568 |
dc.relation.publisherversion | https://doi.org/10.3390/jpm11060568 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 2075-4426 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas |
dc.description.peerreviewed | SI |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
EST-Artigos [123]