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dc.contributor.authorRapado González, Óscar
dc.contributor.authorMartínez Reglero, Cristina
dc.contributor.authorSalgado Barreiro, Ángel
dc.contributor.authorMuinelo Romay, Laura
dc.contributor.authorLópez López, Rafael
dc.contributor.authorMuinelo Lorenzo, Juan
dc.contributor.authorLópez López, Rafael
dc.contributor.authorDíaz Lagares, Ángel
dc.contributor.authorSuárez Cunqueiro, María Mercedes
dc.date.accessioned2021-08-06T13:15:38Z
dc.date.available2021-08-06T13:15:38Z
dc.date.issued2021
dc.identifier.citationJ. Pers. Med. 2021, 11(6), 568; https://doi.org/10.3390/jpm11060568
dc.identifier.urihttp://hdl.handle.net/10347/26711
dc.description.abstractDNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis
dc.description.sponsorshipThis work was co-funded by the Instituto de Salud Carlos III (ISCIII) (PI20/01449) and the European Regional Development Fund (FEDER). A.D.-L. is funded by a “Juan Rodés” contract from ISCIII (JR17/00016). L.M.-R. is funded by a “Miguel Servet” contract from ISCIII (CP20/00129)
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDNA methylation
dc.subjectEpigenetics
dc.subjectHead and neck cancer
dc.subjectSaliva
dc.subjectBiomarkers
dc.subjectLiquid biopsy
dc.subjectMeta-analysis
dc.titleSalivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis
dc.typejournal article
dc.identifier.doi10.3390/jpm11060568
dc.relation.publisherversionhttps://doi.org/10.3390/jpm11060568
dc.type.hasVersionVoR
dc.identifier.essn2075-4426
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
dc.description.peerreviewedSI


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
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 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)





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