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dc.contributor.authorDomingues, Tiago
dc.contributor.authorGrabowska, Anna D.
dc.contributor.authorLee, Ji-Sook
dc.contributor.authorAmeijeiras Alonso, José
dc.contributor.authorWestermeier, Francisco
dc.contributor.authorScheibenbogen, Carmen M.
dc.contributor.authorCliff, Jacqueline Margaret
dc.contributor.authorNacul, Luis
dc.contributor.authorLacerda, Eliana
dc.contributor.authorMouriño, Helena
dc.contributor.authorSepúlveda, Nuno
dc.date.accessioned2021-08-09T11:44:24Z
dc.date.available2021-08-09T11:44:24Z
dc.date.issued2021
dc.identifier.citationFront. Med. 2021, 8:686736. doi: 10.3389/fmed.2021.686736
dc.identifier.urihttp://hdl.handle.net/10347/26725
dc.description.abstractThe evidence of an association between Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and chronic herpesviruses infections remains inconclusive. Two reasons for the lack of consistent evidence are the large heterogeneity of the patients' population with different disease triggers and the use of arbitrary cutoffs for defining seropositivity. In this work we re-analyzed previously published serological data related to 7 herpesvirus antigens. Patients with ME/CFS were subdivided into four subgroups related to the disease triggers: S0-42 patients who did not know their disease trigger; S1-43 patients who reported a non-infection trigger; S2-93 patients who reported an infection trigger, but that infection was not confirmed by a lab test; and S3-48 patients who reported an infection trigger and that infection was confirmed by a lab test. In accordance with a sensitivity analysis, the data were compared to those from 99 healthy controls allowing the seropositivity cutoffs to vary within a wide range of possible values. We found a negative association between S1 and seropositivity to Epstein-Barr virus (VCA and EBNA1 antigens) and Varicella-Zoster virus using specific seropositivity cutoff. However, this association was not significant when controlling for multiple testing. We also found that S3 had a lower seroprevalence to the human cytomegalovirus when compared to healthy controls for all cutoffs used for seropositivity and after adjusting for multiple testing using the Benjamini-Hochberg procedure. However, this association did not reach statistical significance when using Benjamini-Yekutieli procedure. In summary, herpesviruses serology could distinguish subgroups of ME/CFS patients according to their disease trigger, but this finding could be eventually affected by the problem of multiple testing
dc.description.sponsorshipTD, HM, and NS were partially funded by the Fundação para a Ciência e a Tecnologia, Portugal (ref: UIDB/00006/2020 and UIDB/04561/2020). NS, EL, and CS were partially funded by ME Research UK (SCIO Charity Number SC036942) with the financial support of The Fred and Joan Davies Bequest. TD also received travel funding from the EUROMENE Cost Action (ref. CA15111) for a short scientific mission to the London School of Hygiene & Tropical Medicine in 2018. JA-A acknowledged the financial support of the Project MTM2016-76969-P from the Spanish State Research Agency (AEI) co-funded by the European Regional Development Fund (ERDF), the Competitive Reference Groups 2017-2020 (ED431C 2017/38) from the Xunta de Galicia through the ERDF. Research reported in this manuscript was supported by the National Institutes of Health (NIH) under award number 2R01AI103629
dc.language.isoeng
dc.publisherFrontiers Media
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2016-76969-P/ES
dc.rightsCopyright © 2021 Domingues, Grabowska, Lee, Ameijeiras-Alonso, Westermeier, Scheibenbogen, Cliff, Nacul, Lacerda, Mouriño and Sepúlveda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDisease trigger
dc.subjectCutoff value
dc.subjectStratification
dc.subjectEpstein-Barr virus
dc.subjectHuman cytomegalovirus
dc.subjectVaricella-zoster virus
dc.subjectHuman herpesvirus-6
dc.subjectHerpes simplex virus 1 and 2
dc.titleHerpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3389/fmed.2021.686736
dc.relation.publisherversionhttps://doi.org/10.3389/fmed.2021.686736
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2296-858X
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización
dc.description.peerreviewedSI


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Copyright © 2021 Domingues, Grabowska, Lee, Ameijeiras-Alonso, Westermeier, Scheibenbogen, Cliff, Nacul, Lacerda, Mouriño and Sepúlveda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
Except where otherwise noted, this item's license is described as  Copyright © 2021 Domingues, Grabowska, Lee, Ameijeiras-Alonso, Westermeier, Scheibenbogen, Cliff, Nacul, Lacerda, Mouriño and Sepúlveda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms





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