The early-life exposome and epigenetic age acceleration in children
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Título: | The early-life exposome and epigenetic age acceleration in children |
Autor/a: | Prado Bert, Paula de Ruiz-Arenas, Carlos Vives-Usano, Marta Andrusaityte, Sandra Cadiou, Solène Carracedo Álvarez, Ángel María Casas, Maribel Chatzi, Leda Dadvand, Payam González Ruiz, Juan Ramon Grazuleviciene, Regina Gutzkow, Kristine Bjerve Haug, Line Småstuen Hernandez Ferrer, Carles Keun, Hector C. Lepeule, Johanna Maitre, Léa McEachan, Rosemary Nieuwenhuijsen, Mark J. Pelegrí, Dolors Robinson, Oliver Slama, Rémy Vafeiadi, Marina Sunyer, Jordi Vrijheid, Martine Bustamante, Mariona |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría |
Palabras chave: | Aging | Epigenetic age acceleration | Pregnancy | Childhood | Environmental exposures | |
Data: | 2021 |
Editor: | Elsevier |
Cita bibliográfica: | Environment International 2021, 155: 106683. https://doi.org/10.1016/j.envint.2021.106683 |
Resumo: | The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age |
Versión do editor: | https://doi.org/10.1016/j.envint.2021.106683 |
URI: | http://hdl.handle.net/10347/26749 |
DOI: | 10.1016/j.envint.2021.106683 |
ISSN: | 0160-4120 |
Dereitos: | © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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