Evidence of population structuring following population genetic analyses of Fasciola hepatica from Argentina
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Título: | Evidence of population structuring following population genetic analyses of Fasciola hepatica from Argentina |
Autor/a: | Beesley, Nicola Attree, Elizabeth Vázquez Prieto, Severo Vilas Peteiro, Román Paniagua Crespo, María Esperanza Martínez Ubeira, Florencio César Jensen, Oscar Pruzzo, Cesar Álvarez, José D. Malandrini, Jorge Bruno Solana, Hugo Daniel Hodgkinson, Jane E. |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física |
Palabras chave: | Fasciola hepatica | Population genetics | Population structure | Clones | Argentina | |
Data: | 2021 |
Editor: | Elsevier |
Cita bibliográfica: | International Journal for Parasitology 2021, 51(6): 471-480. https://doi.org/10.1016/j.ijpara.2020.11.007 |
Resumo: | Fasciola hepatica, the liver fluke, is a trematode parasite that causes disease of economic importance in livestock. As a zoonosis this parasite also poses a risk to human health in areas where it is endemic. Population genetic studies can reveal the mechanisms responsible for genetic structuring (non-panmixia) within parasite populations and provide valuable insights into population dynamics, which in turn enables theoretical predictions of evolutionary dynamics such as the evolution of drug resistance. Here we genotyped 320 F. hepatica collected from 14 definitive hosts from four provinces in Argentina. STRUCTURE analysis indicated three population clusters, and principal coordinate analysis confirmed this, showing population clustering across provinces. Similarly, pairwise FST values amongst all four provinces were significant, with standardised pairwise FST (F′ST) ranging from 0.0754 to 0.6327. Therefore, population genetic structure was evident across these four provinces in Argentina. However, there was no evidence of deviation from Hardy–Weinberg equilibrium, so it appears that within these sub-populations there is largely random mating. We identified 263 unique genotypes, which gave a clonal diversity of 82%. Parasites with identical genotypes, clones, accounted for 26.6% of the parasites studied and were found in 12 of the 14 hosts studied, suggesting some clonemate transmission |
Versión do editor: | https://doi.org/10.1016/j.ijpara.2020.11.007 |
URI: | http://hdl.handle.net/10347/26771 |
DOI: | 10.1016/j.ijpara.2020.11.007 |
ISSN: | 0020-7519 |
Dereitos: | © 2021 The Author(s). Published by Elsevier Ltd on behalf of Australian Society for Parasitology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) Atribución 4.0 Internacional |
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