The Reactions of Mitomycin C with Dithiols III. Mysterious Reactions
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Título: | The Reactions of Mitomycin C with Dithiols III. Mysterious Reactions |
Autor/a: | Paz Castañal, Manuel María |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Data: | 2010 |
Editor: | MDPI |
Cita bibliográfica: | Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-00484 |
Serie: | Electronic Conference on Synthetic Organic Chemistry;14 |
Resumo: | We report two unexpected findings ocurring after treatment of the antitumor drug mitomycin C with dithiols. The first finding relates to the reaction of mitomycin C with exactly one molar equivalent of dithiol to form a mitosene-like material with unusual physico-chemical properties. The second finding was the formation of unexpected dimeric mitosenes when the reaction of MC with dithiols was quenched at short reaction times. We hypothesize that both events are originated by an unprecedetended deaziridination reaction |
Descrición: | The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry |
Versión do editor: | https://doi.org/10.3390/ecsoc-14-00484 |
URI: | http://hdl.handle.net/10347/26884 |
DOI: | 10.3390/ecsoc-14-00484 |
ISBN: | 3-906980-24-3 |
Dereitos: | © 2010 The author(s). Published by MDPI, Basel, Switzerland. Open Access |