Synthetic Supramolecular Systems in Life-like Materials and Protocell Models
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Título: | Synthetic Supramolecular Systems in Life-like Materials and Protocell Models |
Autor/a: | Insua López, Ignacio Montenegro García, Javier |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | Supramolecular chemistry | Self-assembly | Life-like materials | Synthetic cells | Biomimicry | Protocells | |
Data: | 2020 |
Editor: | Elsevier |
Cita bibliográfica: | I. Insua, J. Montenegro, Chem 2020, 6(7), 1652-1682 |
Resumo: | One of the biggest challenges in modern chemistry is the preparation of synthetic materials with life-like behavior for the assembly of artificial cells. In recent years, numerous artificial systems that mimic cellular components and functions have been developed. Supramolecular chemistry plays a key role in such cell mimics given that non-covalent interactions control the shape and function of many biomolecules, such as DNA base pairing, protein structure, ligand-receptor binding, and lipid membrane packing. However, the complexity of living cells constitutes a major challenge for their bottom-up assembly from pure synthetic materials. Inspired by the building blocks of nature, a wide range of supramolecular systems have been developed to reproduce cellular functions such as cell-cell communication, signaling cascades, and dynamic cytoskeleton assemblies. This review surveys a selection of key advances in synthetic derivatives of biomolecules with supramolecular organization and life-like behavior by addressing their non-covalent foundation and integration as increasingly complex protocell models |
Versión do editor: | https://doi.org/10.1016/j.chempr.2020.06.005 |
URI: | http://hdl.handle.net/10347/26916 |
DOI: | 10.1016/j.chempr.2020.06.005 |
ISSN: | 2451-9294 |
Dereitos: | © 2020 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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- CIQUS-Artigos [475]
- QO-Artigos [436]
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