Sequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides
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Título: | Sequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides |
Autor/a: | Díaz Arias, Sandra Natalia Insua López, Ignacio Bhak, Ghibom Montenegro García, Javier |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | 2D | Nanosheet | Nanotube | Self-assembly | Supramolecular chemistry | |
Data: | 2020 |
Editor: | Wiley |
Cita bibliográfica: | S. Díaz, I. Insua, G. Bhak, J. Montenegro, Chem. Eur. J. 2020, 26, 14765 |
Resumo: | The inherent ability of peptides to self-assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two-dimensional (2D) supramolecular biomaterials. However, the design of peptides with hierarchical assembly in different dimensions across mesoscopic lengths remains a challenging task. We here describe the structural exploration of a d/l-alternating cyclic octapeptide capable of assembling one-dimensional (1D) nanotubes in water, which subsequently pack laterally to form giant 2D nanosheets up to 500 μm long with a constant 3.2 nm thickness. Specific amino acid mutations allowed the mapping of structure–assembly relationships that determine 2D self-assembly. Nine peptide modifications were studied, revealing key features in the peptide sequence that nanosheets tolerated, while a total of three peptide variants included modifications that compromised their 2D arrangement. These lessons will serve as guide and inspiration for new 2D supramolecular peptide designs |
Descrición: | This is the peer reviewed version of the following article: S. Díaz, I. Insua, G. Bhak, J. Montenegro, Chem. Eur. J. 2020, 26, 14765, which has been published in final form at https://doi.org/10.1002/chem.202003265. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Versión do editor: | https://doi.org/10.1002/chem.202003265 |
URI: | http://hdl.handle.net/10347/26918 |
DOI: | 10.1002/chem.202003265 |
ISSN: | 0947-6539 |
E-ISSN: | 1521-3765 |
Dereitos: | © 2020 Wiley-VCH Verlag GmbH. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions |
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