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dc.contributor.authorDíaz Arias, Sandra Natalia
dc.contributor.authorInsua López, Ignacio
dc.contributor.authorBhak, Ghibom
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2021-09-06T17:11:39Z
dc.date.issued2020
dc.identifier.citationS. Díaz, I. Insua, G. Bhak, J. Montenegro, Chem. Eur. J. 2020, 26, 14765
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10347/26918
dc.descriptionThis is the peer reviewed version of the following article: S. Díaz, I. Insua, G. Bhak, J. Montenegro, Chem. Eur. J. 2020, 26, 14765, which has been published in final form at https://doi.org/10.1002/chem.202003265. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.description.abstractThe inherent ability of peptides to self-assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two-dimensional (2D) supramolecular biomaterials. However, the design of peptides with hierarchical assembly in different dimensions across mesoscopic lengths remains a challenging task. We here describe the structural exploration of a d/l-alternating cyclic octapeptide capable of assembling one-dimensional (1D) nanotubes in water, which subsequently pack laterally to form giant 2D nanosheets up to 500 μm long with a constant 3.2 nm thickness. Specific amino acid mutations allowed the mapping of structure–assembly relationships that determine 2D self-assembly. Nine peptide modifications were studied, revealing key features in the peptide sequence that nanosheets tolerated, while a total of three peptide variants included modifications that compromised their 2D arrangement. These lessons will serve as guide and inspiration for new 2D supramolecular peptide designs
dc.description.sponsorshipThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], Xunta de Galicia (AD031 2016, ED431C 2017/25 and ED431G2019/03) and the European Commission (EC) (European Regional Development Fund-ERDF) Instituto de Salud Carlos III (COV20/00297). I.I. thanks the European Commission (EC) and AEI for MSCA-IF (2018-843332) and Juan de la Cierva (FJCI-2017-31795) fellowships, respectively. J.M. thanks the Ramón y Cajal (RYC-2013-13784), ERC- STG (DYNAP, 2016-677786), ERC-POC (TraffikGene, 2019-838002) and Human Frontier Science Programme Young Investigator Grant (RGY0066/2017) for funding
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES
dc.rights© 2020 Wiley-VCH Verlag GmbH. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.subject2D
dc.subjectNanosheet
dc.subjectNanotube
dc.subjectSelf-assembly
dc.subjectSupramolecular chemistry
dc.titleSequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/chem.202003265
dc.relation.publisherversionhttps://doi.org/10.1002/chem.202003265
dc.description.embargo2021-10-12
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1521-3765
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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