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dc.contributor.advisor | Salas Ellacuriaga, Antonio |
dc.contributor.advisor | Martinón Torres, Federico (dir.) |
dc.contributor.author | Pischedda, Sara |
dc.date.accessioned | 2021-10-13T08:16:38Z |
dc.date.available | 2021-10-13T08:16:38Z |
dc.date.issued | 2021 |
dc.identifier.uri | http://hdl.handle.net/10347/26993 |
dc.description.abstract | Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject | Epigenetics |
dc.subject | Immune System |
dc.subject | Childhood |
dc.subject | Infectious Diseases |
dc.subject | Vaccines |
dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320505 Enfermedades infecciosas |
dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320110 Pediatría |
dc.subject.classification | Materias::Investigación::24 Ciencias de la vida::2410 Biología humana::241007 Genética humana |
dc.title | Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines |
dc.type | doctoral thesis |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
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