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dc.contributor.authorCarnero Groba, Bastián
dc.contributor.authorBao Varela, María del Carmen
dc.contributor.authorGómez Varela, Ana Isabel
dc.contributor.authorÁlvarez Castro, Ezequiel
dc.contributor.authorFlores Arias, María Teresa
dc.date.accessioned2022-03-17T08:16:03Z
dc.date.available2022-03-17T08:16:03Z
dc.date.issued2021
dc.identifier.citationMaterials Science and Engineering C 129 (2021) 112388. https://doi.org/10.1016/j.msec.2021.112388
dc.identifier.urihttp://hdl.handle.net/10347/27676
dc.description.abstractStereolithographic printers have revolutionized many manufacturing processes with their capacity to easily produce highly detailed structures. In the field of microfluidics, this technique avoids the use of complex steps and equipment of the conventional technologies. The potential of low force stereolithography technology is analysed for the first time using a Form 3B printer and seven printing resins through the fabrication of microchannels and pillars. Manufacturing performance of internal and superficial channels and pillars is studied for the seven printing resins in different configurations. A complete characterization of printed structures is carried out by optical, confocal and SEM microscopy, and EDX analysis. Internal channels with unobstructed lumen are obtained for diameters and angles greater than 500 μm and 60°, respectively. Outward and inward superficial channels in the range of hundreds of microns can be fabricated with an accurate profile, printing them with a perpendicular orientation respect to the base, allowing a proper uncured resin evacuation. Outward channels are replicated by soft lithography using polydimethylsiloxane. Clear, Model and Tough resins show a good behaviour to be used as master, but Amber and Dental resins present a poor topology transference from the master to the replica. According to the needs of devices used for biological and biomedical research, transparency as well as superficial biocompatibility of some resins is evaluated. Human umbilical vein endothelial cells (HUVEC) adhesion is confirmed on Amber, Dental and Clear resins, but these cells were only able to grow and progress as a cell culture over the Amber resin. Therefore, Amber showed an adequate biocompatibility, in terms of cell adhesion and growth for HUVEC
dc.description.sponsorshipAuthors gratefully thank contracts AEI RTI2018-097063-B-100, AEI/FEDER, UE; ED431B 2020/29; ED431E 2018/08 and ED481D-2021-019, Consellería de Educación Xunta de Galicia/FEDER e Estructuración Xunta de Galicia, IN607A2019-02 and Sociedad española de cardiología y Fundación español del corazón, SEC/FEC-INV-BAS 20/013
dc.language.isoeng
dc.publisherElsevier
dc.rights© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectStereolithography
dc.subjectLow force stereolithography
dc.subjectMicrofluidics
dc.subjectOrgan-on-a-chip
dc.subject3D printing
dc.subjectMicrochannel
dc.subjectPillar
dc.subjectSoft lithography
dc.subjectPDMS
dc.subjectBiocompatibility
dc.subjectHUVEC
dc.titleMicrofluidic devices manufacturing with a stereolithographic printer for biological applications
dc.typejournal article
dc.identifier.doi10.1016/j.msec.2021.112388
dc.relation.publisherversionhttps://doi.org/10.1016/j.msec.2021.112388
dc.type.hasVersionVoR
dc.identifier.essn0928-4931
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física Aplicada
dc.description.peerreviewedSI
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI 2018-097063-B-100/ES


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Mostrar o rexistro simple do ítem

© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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 © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)





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