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dc.contributor.authorLópez Vázquez, Javier
dc.contributor.authorRodil Rodríguez, María del Rosario
dc.contributor.authorTrujillo Rodríguez, María José
dc.contributor.authorQuintana Álvarez, José Benito
dc.contributor.authorCela Torrijos, Rafael
dc.contributor.authorMiró Lladó, Manuel
dc.date.accessioned2022-03-23T12:58:00Z
dc.date.available2022-03-23T12:58:00Z
dc.date.issued2022
dc.identifier.citationScience of The Total Environment 826 (2022) 154027
dc.identifier.urihttp://hdl.handle.net/10347/27719
dc.descriptioninfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117686RB-C33/ES/PLATAFORMAS ANALITICAS FLUIDICAS PARA EVALUAR LA EXPOSICION HUMANA Y AMBIENTAL A CONTAMINANTES EMERGENTES
dc.description.abstractNotwithstanding the fact that microplastic fragments were encountered in the human stool, little effort has been geared towards elucidating the impact of chemical additives upon the human health. In this work, standardized bioaccessibility tests under both fasting and fed conditions are herein applied to the investigation of human oral bioaccessibility of plastic additives and monomers (i.e. eight phthalate esters (PAEs) and bisphenol A (BPA)) in low-density polyethylene (LDPE) and polyvinyl chloride (PVC) microplastics. The generation of phthalate monoesters is evaluated in the time course of the bioaccessibility tests. Maximum gastric and gastrointestinal bioaccessibility fractions are obtained for dimethyl phthalate, diethyl phthalate and BPA, within the range of 55–83%, 40–68% and 37–67%, respectively, increasing to 56–92% and 41–70% for dimethyl phthalate and diethyl phthalate, respectively, whenever their hydrolysis products are considered. Bioaccessibility fractions of polar PAEs are dependent upon the physicochemical characteristics of the microplastics, with greater bioaccessibility for the rubbery polymer (LDPE). With the method herein proposed, oral bioaccessible pools of moderately to non-polar PAEs can be also accurately assessed for risk-assessment explorations, with values ranging from 1.8% to 32.2%, with again significantly larger desorption percentages for LDPE. Our results suggested that the highest gastric/gastrointestinal bioaccessibility of the eight PAEs and BPA is reached under fed-state gastrointestinal extraction conditions because of the larger amounts of surface-active biomolecules. Even including the bioaccessibility factor within human risk assessment/exposure studies to microplastics, concentrations of dimethyl phthalate, di-n-butyl phthalate and BPA exceeding 0.3% (w/w) may pose severe risks after oral uptake in contrast to the more hydrophobic congeners for which concentrations above 3% (w/w), except for diethylhexyl phthalate, would be tolerated
dc.description.sponsorshipThe authors acknowledge the financial support provided by the Spanish Ministry of Science and Innovation (MCIN) and Spanish State Research Agency (AEI/10.13039/501100011033) through the projects CTM2017-84763-C3-2-R, CTM2017-84763-C3-3-R, CTM2017-90890-REDT, PID2020-117686RB-C32 and PID2020-117686RB-C33, by the “ERDF-A way of making Europe”, by the Galician Government (Consellería de Economía e Industria, Xunta de Galicia, ref. ED431C 2021/06) and by La Caixa–Fundación CajaCanarias for MJT-R contract. We would like to express our gratitude to Restek (kind gift of the Biphenyl column). The technical support on SEM images by Dr. Ferran Hierro from the Scientific and Technological Centre at the UIB is greatly acknowledged
dc.language.isoeng
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTM2017-84763-C3-2-R/ES/EVALUACION DEL EXPOSOMA DE CONTAMINANTES EMERGENTES EN AMBIENTES ACUATICOS
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTM2017-84763-C3-3-R/ES/EVALUACION DEL EXPOSOMA DE CONTAMINANTES EMERGENTES EN AMBIENTES ACUATICOS
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117686RB-C33/ES/PLATAFORMAS ANALITICAS FLUIDICAS PARA EVALUAR LA EXPOSICION HUMANA Y AMBIENTAL A CONTAMINANTES EMERGENTES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117686RB-C32/ES/EVALUACION DE LA EXPOSICION HUMANA Y AMBIENTAL A CONTAMINANTES QUIMICOS DE ESPECIAL RELEVANCIA
dc.rights© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioaccessibility
dc.subjectBisphenol A
dc.subjectChromatography
dc.subjectHydrolysis products
dc.subjectMass spectrometry
dc.subjectMicroplastics
dc.subjectPhthalates
dc.titleMimicking human ingestion of microplastics: oral bioaccessibility tests of bisphenol A and phthalate esters under fed and fasted states
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.scitotenv.2022.154027
dc.relation.publisherversionhttps://doi.org/10.1016/j.scitotenv.2022.154027
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn0048-9697
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.description.peerreviewedSI


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© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as  © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/





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