The impact of transposable elements on the structure and function of the cancer genome
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http://hdl.handle.net/10347/28860
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Título: | The impact of transposable elements on the structure and function of the cancer genome |
Autor/a: | Rodríguez Martín, Bernardo |
Dirección/Titoría: | Castro Tubío, José Manuel |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
Palabras chave: | Retrotransposones | Cancer | Biología Computacional | |
Data: | 2022 |
Resumo: | This PhD dissertation provides further insights on the impact of retrotransposon mobilisation in the cancer genome. Through the analysis of a large cohort of 2,954 cancer whole genomes compiled by the Pan-Cancer Analysis of Whole Genomes Consortium, we have investigated the patterns of somatic activity for mobile elements across 38 different tumour types, uncovered novel mechanisms of mutation mediated by LINE-1 elements and characterised more than 100 full-length LINE-1 loci active in cancer. |
URI: | http://hdl.handle.net/10347/28860 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- Área de Ciencias da Saúde [1252]
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