Now showing items 1-20 of 5694

    • 1,7-Naphthodiyne: a new platform for the synthesis of novel, sterically congested PAHs 

      Pozo Míguez, Iago; Cobas Martínez, Agustín; Peña Gil, Diego; Guitián Rivera, Enrique; Pérez Meirás, María Dolores (Royal Society of Chemistry, 2016-03-17)
      The synthesis of an efficient precursor of the novel 1,7-naphthodiyne synthon is reported. Preliminary experiments demonstrate the usefulness of this platform for the synthesis of sterically congested polyarenes, such as ...
    • 10,000 years of climate control over carbon accumulation in an Iberian bog (southwestern Europe) 

      Pontevedra Pombal, Francisco Javier; Castro Fernández, Daniel; Souto Souto, Martín; Fraga Vila, María Isabel; Blake, William H.; Blaauw, Maarten; López Sáez, José Antonio; Pérez Díaz, Sebastián; Valcárcel Díaz, Marcos Carmelo; García-Rodeja Gayoso, Eduardo (Elsevier, 2019)
      The northwest region of the Iberian Peninsula is home to a unique ecosystem of bogs, which are particularly sensitive to projected climate change. In this context, the rate of carbon (C) accumulation in Chao de Veiga Mol, ...
    • 100 años de la Biblioteca América de la Universidad de Santiago 

      Cagiao Vila, María Pilar; Rey Tristán, Eduardo (Consejo Superior de Investigaciones Científicas (CSIC), 2004)
    • 131 conceptos clave de educación social 

      Caballo Villar, María Belén; Candia Durán, Francisco Xosé; Caride Gómez, José Antonio; Meira Cartea, Pablo Ángel (Universidade de Santiago de Compostela. Servizo de Publicacións e Intercambio Científico, 1997)
      Definición en galego dos 131 conceptos máis importantes que se empregan na teoría e práctica da Educación Social. Os conceptos (ou expresións) ofrécense numerados, ordenados alfabeticamente e explicados en aproximadamente 20 liñas
    • 14N NMR spectroscopy study of binding interaction between sodium azide and hydrated fullerene 

      Chachibaia, Tamar; Martín Pastor, Manuel (MDPI, 2017)
      Our study is the first attempt to study the interaction between NaN3 and hydrated fullerenes C60 by means of a non-chemical reaction-based approach. The aim is to study deviations of signals obtained by 14N NMR spectroscopy ...
    • 1D to 2D Self Assembly of Cyclic Peptides 

      Insua López, Ignacio; Montenegro García, Javier (American Chemical Society, 2020)
      Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic ...
    • (1RS,4RS,5RS)-Methyl 2-(3,5-di­nitro­benzo­yl)-2-oxa-3-aza­bi­cyclo­[3.3.0]oct-7-ene-4-carboxyl­ate 

      Sousa, Carlos A.D.; Rodríguez Borges, José E.; Vale, M. Luísa C.; García Mera, Xerardo Xusto (International Union of Crystallography, 2009)
      In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to ...
    • [2+1] Cycloaddition of Catalytic Ruthenium Vinyl Carbenes: A Stereoselective Controlled Access to (Z)- and (E)-Vinyl Epoxypyrrolidines 

      Padín Santos, Damián; Cambeiro Cambeiro, Fermín; Fañanás Mastral, Martín; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2016)
      Aza-alkynals undergo a cyclization reaction with diazo compounds in the presence of catalytic amounts of Cp*RuCl(cod) to afford vinyl epoxypyrrolidines, valuable building blocks for the synthesis of biologically active ...
    • A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms 

      Barral Arca, Ruth; Pardo Seco, Jacobo José; Martinón Torres, Federico; Salas Ellacuriaga, Antonio (Nature Publishing Group, 2018)
      Recently, a biomarker signature consisting of 2-transcript host RNAs was proposed for discriminating bacterial from viral infections in febrile children. We evaluated the performance of this signature in a different disease ...
    • 2000-2017: años dorados y oscuros para la prensa de distribución gratuita en España 

      Bellón Rodríguez, Ana (Universidad Nacional de La Plata, 2018)
      Los diarios de distribución gratuita, información general y ámbito nacional se convirtieron en España en un fenómeno en el tránsito del siglo XX al XXI. Ese fenómeno, ahora, ha quedado reducido a la mínima expresión. Se ...
    • 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients 

      Sartelli, Massimo; McFarland, Lynne V.; Khanna, Sahil; Furuya Kanamori, Luis; Abuzeid, Nadir; Abu-Zizan, Fikri M.; Ansaloni, Luca; Agustin, Goran; Bala, Miklosh; Ben-Ishay, Offir; Biffl, Walter L.; Brecher, Stephen M.; Camacho Ortiz, Adrián; Caínzos Fernández, Miguel Ángel; Chan, Shirley; Cherry-Bukowiec, Jill R.; Clanton, Jesse; Coccolini, Federico; Cocuz, María E.; Coimbra, Raúl; Cortese, Francesco; Cui, Yunfeng; Czepiel, Jacek; Demetrashvili, Zaza; Di Carlo, Isidoro; Di Saverio, Salomone; Dumitru, Irina M.; Eckmann, Christian; Eiland, Edward H.; Forrester, Joseph D.; Fraga, Gustavo P.; Frossard, Jean L.; Fry, Donald E.; Galeiras, Rita; Ghnnam, Wagih; Gomes, Carlos A.; Griffiths, Ewen A.; Guirao, Xavier; Ahmed, Mohamed H.; Herzog, Torsten; Kim, Jae II; Iqbal, Tariq; Isik, Arda; Itani, Kamal M.F.; Labricciosa, Francesco M.; Lee, Yeong Y.; Juang, Paul; Karamarkovic, Aleksandar; Kim, Peter K.; Kluger, Yoram; Leppaniemi, Ari; Lohsiriwat, Varut; Machain, Gustavo M.; Marwah, Sanjay; Mazuski, John E.; Metan, Gokhan; Moore, Ernest E.; Moore, Frederick A.; Ordoñez, Carlos A.; Pagani, Leonardo; Petrosillo, Nicola; Portela, Francisco; Rasa, Kemal; Rems, Miran; Sakakushev, Boris E.; Segovia-Lohse, Helmut; Sganga, Gabriele; Shelat, Vishal G.; Spigaglia, Patrizia; Tattevin, Pierre; Tranà, Cristian; Urbánek, Libor; Ulrych, Jan; Viale, Pierluigi; Catena, Fausto; Di Bella, Stefano (BMC, 2019)
      In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and severity in many countries worldwide. The increase in CDI incidence has been particularly apparent among surgical patients. ...
    • 26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines 

      Seoane Ruzo, Samuel; Álvarez Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro Saavedra, Miguel Anxo; Mouriño Mosquera, Antonio; Pérez Fernández, Román (MDPI, 2013)
      It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
    • 3-O-Benzyl-6-O-benzoyl-1,2-Oisopropilidene-5-C-nitromethyl-a-Dglucofuranose 

      Pampín Casal, María Begoña; Valencia Matarranz, Laura; Estévez Cabanas, Juan Carlos; Estévez Cabanas, Ramón José (International Union of Crystallography, 2008)
      The title compound, C24H27NO9, is one of the epimers of the Henry reaction of 3-O-benzyl-6-O-benzoyl-2-O-isopropyl­idene-a-D-glucofuran-5-one with nitro­methane. The conformation of the five membered rings is as expected ...
    • 3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology 

      Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2019)
      [ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the ...
    • 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients 

      Awad, Atheer; Yao, Aliya; Trenfield, Sarah J.; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2020)
      Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating ...
    • 3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease 

      Seoane Viaño, Iria; Gómez Lado, Noemí; Lázare Iglesias, Héctor; García Otero, Xurxo; Antúnez López, José Ramón; Ruibal Morell, Álvaro; Varela Correa, Juan Jesús; Aguiar Fernández, Pablo; Basit, Abdul W.; Otero Espinar, Francisco Javier; González Barcia, Miguel; Goyanes Goyanes, Álvaro; Luzardo Álvarez, Asteria María; Fernández Ferreiro, Anxo (MDPI, 2020)
      The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel ...
    • 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method 

      Robles Martínez, Pamela; Xu, Xiaoyan; Trenfield, Sarah J.; Awad, Atheer; Goyanes Goyanes, Álvaro; Telford, Richard; Basit, Abdul W.; Gaisford, Simon (MDPI, 2019)
      Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise ...
    • [4+2] and [4+3] catalytic cycloadditions of allenes 

      López García, Fernando; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2014)
      This feature review describes the development of catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for assembling six and seven-membered cyclic systems. The different methodologies ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...





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