Institutos e Centros de Investigación
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Proceedings of the 1st Doctoral Consortium at the European Conference on Artificial Intelligence (DC-ECAI 2020)
(2020)The DC-ECAI 2020 provides a unique opportunity for PhD students, who are close to finishing their doctorate research, to interact with experienced researchers in the field. Senior members of the community are assigned as ... -
Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells
(Elsevier, 2019)Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ... -
Polyphosphazenes for the delivery of biopharmaceuticals
(Wiley, 2020)Polyphosphazenes (PPZs) are a relatively new family of polymers based on a nitrogen- phosphorous backbone where organic side-groups can be grafted. The synthetic route to PPZs is highly versatile such that it is possible ... -
Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells
(Elsevier, 2020)Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the ... -
Structure-optimized interpolymer polyphosphazene complexes for effective gene delivery to glioblastoma
(Wiley, 2019)Safe and efficient gene delivery vectors would enhance the prospects for polynucleotide-based therapies. Herein we describe a new approach towards structurally-optimized gene vector design based on the preparation of ...
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