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  • Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies 

    GONZALEZ-BELLO, CONCEPCION (Bentham Science, 2016)
    The loss of effectiveness of current antibiotics caused by the development of drug resistance has become a severe threat to public health. Current widely used antibiotics are surprisingly targeted at a few bacterial functions ...
  • Antibiotic adjuvants – A strategy to unlock bacterial resistance to antibiotics 

    GONZALEZ-BELLO, CONCEPCION (Elsevier, 2017-08-14)
    Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to multiple types of antibiotics has increased dramatically each year and has spread ...
  • A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves 

    Rodríguez, Jéssica; Mosquera, Jesús; García-Fandiño, Rebeca; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2016-02-05)
    We report the rational design of a DNA-binding peptide construct composed of the DNA-contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook DNA anchor. The resulting chimera, which ...
  • Transition metal catalysis in the mitochondria of living cells 

    Tomás Gamasa, María; Martínez Calvo, Miguel; Couceiro, José R.; Mascareñas Cid, José Luis (Nature Publishing Group, 2016-09-07)
    The development of transition metal catalysts capable of promoting non-natural transformations within living cells can open significant new avenues in chemical and cell biology. Unfortunately, the complexity of the cell ...
  • A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance 

    Martins, Luís; Seoane-Collazo, Patricia; Contreras, Cristina; González-García, Ismael; Martínez Sánchez, Noelia; González, Francisco; Zalvide, Juan; Gallego, Rosalía; Diéguez González, Carlos; Nogueiras, Ruben; Tena-Sempere, Manuel; López, Miguel (Elsevier, 2016-08-11)
    AMP-activated protein kinase (AMPK) in the ventromedial nucleus of the hypothalamus (VMH) and orexin (OX) in the lateral hypothalamic area (LHA) modulate brown adipose tissue (BAT) thermogenesis. However, whether these two ...

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