• Membrane-disrupting iridium(III) oligocationic organometallopeptides 

  Salvadó, Iria; Gambia, Ilaria; Montenegro, Javier; Martínez-Costas, Jose; Brea, José Manuel; Loza, María Isabel; Vázquez López, Miguel; Vazquez Sentis, M. Eugenio (Royal Society of Chemistry, 2016-08-19)

  A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ...

• Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017 

  Montenegro, Javier; Phipps, Robert (Royal Society of Chemistry, 2017-08-24)

  The strong wind that was blowing in Brunnen on the 4th of May 2017 was prophetic of the storm of ideas and creativity that would later fall over the participants of the 52nd edition of the Bürgenstock conference. The ...

• Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites 

  Fuertes, Alberto; Juanes, Marisa; Granja, Juan; Montenegro, Javier (Royal Society of Chemistry, 2017-06-09)

  The fabrication of functional molecular devices constitutes one of the most important current challenges for chemical sciences. The complex processes accomplished by living systems continuously demand the assistance of ...

• Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters 

  Fernández, David; Gulías, Moisés; Mascareñas Cid, José Luis; López, Fernando (Wiley, 2017-07-12)

  A catalytic, versatile and atom-economical C−H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a ...

• Biomaterials to suppress cancer stem cells and disrupt their tumoral niche 

  Garcia-Mazas, Carla; Csaba, Noemi; Garcia-Fuentes, Marcos (Elsevier, 2017-05-25)

  Lack of improvement in the treatment options of several types of cancer can largely be attributed to the presence of a subpopulation of cancer cells with stem cell signatures and to the tumoral niche that supports and ...

Ver máis