• Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy 

  Jiang, Bo; Aliyan, Amir; Cook, Nathan P.; Augustine, Andrea; Bhak, Ghibom; Maldonado, Rodrigo; Smith McWilliams, Ashleigh D.; Flores, Erick M.; Mendez, Nicolas; Shahnawaz, Mohammad; Godoy, Fernando J.; Montenegro García, Javier; Moreno-Gonzalez, Ines; Martí, Angel A. (American Chemical Society, 2019-10)

  The formation of oligomeric soluble aggregates is related to the toxicity of amyloid peptides and proteins. In this manuscript, we report the use of a ruthenium polypyridyl complex ([Ru(bpy)2(dpqp)]2+) to track the formation ...

• Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity 

  Sánchez, Mateo I.; Rama, Gustavo; Calo Lapido, Renata; Ucar, Kübra; Lincoln, Per; Vázquez López, Miguel; Melle-Franco, Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2019)

  We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor ...

• Direct protein quantification in complex sample solutions by surface-engineered nanorod probes 

  Schrittwieser, Stefan; Pelaz García, Beatriz; Parak, Wolfgang J.; Lentijo-Mozo, Sergio; Soulantica, Katerina; Dieckhoff, Jan; Ludwig, Frank; Schotter, Joerg (Springer Nature, 2017)

  Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and ...

• Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo 

  Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; Pino, Pablo del; Menao, Sebastián; Heras, Marcelo de las; Arias, Maykel; Mitchell, Scott G.; Pelaz García, Beatriz; Gálvez, Eva M.; Martínez de la Fuente, Jesús; Pardo, Julián (BioMed Central, 2017)

  Background The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect ...

• Nanoparticles engineered to bind cellular motors for efficient delivery 

  Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)

  Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...

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