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  • Pharmacological inactivation of the prion protein by targeting a folding intermediate 

    Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Rigoli, Marta; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Bonaldo, Valerio; Maietta, Giulia; López Lorenzo, Nuria; Fernández Flores, Leticia Camila; Bugallo Codeseira, Yaiza; Tosatto, Laura; Linsenmeier, Luise; Vignoli, Beatrice; Petris, Gianluca; Gasparotto, Dino; Pennuto, Maria; Guella, Graziano; Canossa, Marco; Altmeppen, Hermann C.; Lolli, Graziano; Biressi, Stefano; Martín Pastor, Manuel; Rodríguez Requena, Jesús; Mancini, Ines; Barreca, Maria L.; Faccioli, Pietro; Biasini, Emiliano (Springer Nature, 2021)
    Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. These ...
  • A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer’s disease 

    El-Sappagh, Shaker; Alonso Moral, José María; Islam, Sumaiya M. Riazul; Sultan, Ahmad M.; Kwak, Kyung-Sup (Springer Nature, 2021)
    Alzheimer’s disease (AD) is the most common type of dementia. Its diagnosis and progression detection have been intensively studied. Nevertheless, research studies often have little effect on clinical practice mainly due ...
  • Microbial inefficient substrate use through the perspective of resource allocation models 

    Regueira López, Alberte; Lema Rodicio, Juan Manuel; Mauricio Iglesias, Miguel (Elsevier, 2021)
    Microorganisms extract energy from substrates following strategies that may seem suboptimal at first glance. Beyond the so-called yield-rate trade-off, resource allocation models, which focus on assigning different functional ...
  • Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins 

    Morafraile, Esther C.; Bugallo, Alberto; Carreira Rodríguez, Raquel; Fernández, María; Martín Castellanos, Cristina; González Blanco, Miguel; Segurado, Mónica (Oxford University Press, 2020)
    The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in ...
  • Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity 

    González Rodríguez, María; Ruiz Fernández, Clara; Vera, Francisco; Ait Eldjoudi, Djedjiga; Ramadan Farrag Abdel Hafez, Yousof; Cordero Barreal, Alfonso; Pino Mínguez, Jesús; Lago Paz, María Francisca; Campos Toimil, Manuel; Carvalho, Glaucimeire Rocha; Pereira, Thiago Melo Costa; Gualillo, Oreste (MDPI, 2021)
    Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk ...

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