• Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

  Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)

  Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...

• Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells 

  Martínez Ledo, Adriana; Vining, Kyle H.; Alonso Fernández, María José; García Fuentes, Marcos; Mooney, David J. (Elsevier, 2020)

  Gene delivery within hydrogel matrices can potentially direct mesenchymal stem cells (MSCs) towards a chondrogenic fate to promote regeneration of cartilage. Here, we investigated whether the mechanical properties of the ...

• mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering 

  Martínez Ledo, Adriana; Senra, Ana; Rilo Álvarez, Héctor; Borrajo Alonso, Erea; Vidal Figueroa, Anxo; Alonso Fernández, María José; García Fuentes, Marcos (Elsevier, 2020)

  Gene-activated matrices (GAMs) encoding pivotal transcription factors (TFs) represent a powerful tool to direct stem cell specification for tissue engineering applications. However, current TF-based GAMs activated with ...

• The intracellular angiotensin system buffersdeleterious effects of the extracellular paracrine system 

  Villar Cheda, Begoña; Costa Besada, María Alicia; Valenzuela Limiñana, Rita; Pérez Costas, Emma; Meléndez Ferro, Miguel; Labandeira García, José Luis (Nature Publishing Group, 2017)

  The‘classical’renin–angiotensin system (RAS) is a circulating system that controls blood pressure. Local/paracrine RAS,identified in a variety of tissues, including the brain, is involved in different functions and diseases, ...

• The expression of virulence factors in vibrio anguillarum is dually regulated by iron levels and temperature 

  Afonso Lages, Marta; Balado Dacosta, Miguel; Lemos Ramos, Manuel Luís (Frontiers Media, 2019)

  Vibrio anguillarumcauses a hemorrhagic septicemia that affects cold- and warm-wateradapted fish species. The main goal of this work was to determine the temperature-dependent changes in the virulence factors that could ...

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