• Pharmacological inactivation of the prion protein by targeting a folding intermediate 

  Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Rigoli, Marta; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Bonaldo, Valerio; Maietta, Giulia; López Lorenzo, Nuria; Fernández Flores, Leticia Camila; Bugallo Codeseira, Yaiza; Tosatto, Laura; Linsenmeier, Luise; Vignoli, Beatrice; Petris, Gianluca; Gasparotto, Dino; Pennuto, Maria; Guella, Graziano; Canossa, Marco; Altmeppen, Hermann C.; Lolli, Graziano; Biressi, Stefano; Martín Pastor, Manuel; Rodríguez Requena, Jesús; Mancini, Ines; Barreca, Maria L.; Faccioli, Pietro; Biasini, Emiliano (Springer Nature, 2021)

  Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. These ...

• An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair 

  Cipriani, Filippo; Ariño Palao, Blanca; González de Torre, Israel; Vega Castrillo, Aurelio; Aguado Hernández, Héctor José; Alonso Rodrigo, Matilde; Álvarez Barcia, Ángel José; Sánchez, Ana; García Diaz, Verónica; López Peña, Mónica; Rodríguez Cabello, José Carlos (Oxford University Press, 2019)

  The aim of this study was to evaluate injectable, in situ cross-linkable elastin-like recombinamers (ELRs) for osteochondral repair. Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal ...

• Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins 

  Morafraile, Esther C.; Bugallo, Alberto; Carreira Rodríguez, Raquel; Fernández, María; Martín Castellanos, Cristina; González Blanco, Miguel; Segurado, Mónica (Oxford University Press, 2020)

  The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in ...

• Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity 

  González Rodríguez, María; Ruiz Fernández, Clara; Vera, Francisco; Ait Eldjoudi, Djedjiga; Ramadan Farrag Abdel Hafez, Yousof; Cordero Barreal, Alfonso; Pino Mínguez, Jesús; Lago Paz, María Francisca; Campos Toimil, Manuel; Carvalho, Glaucimeire Rocha; Pereira, Thiago Melo Costa; Gualillo, Oreste (MDPI, 2021)

  Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk ...

• Changes in the Splenic Melanomacrophage Centre Surface Area in Southern Bluefin Tuna (Thunnus maccoyii) Are Associated with Blood Fluke Infections 

  Nowak, Barbara F.; Dang, Mai; Webber, Claire; Neumann, Lukas; Bridle, Andrew; Bermúdez Pose, Roberto; Evans, Daryl (MDPI, 2021)

  Melanomacrophage centres (MMCs) are aggregates of macrophages accumulating various pigments. They have been proposed as an indicator of fish immune response. Blood flukes are common parasites in farmed fish. Two cohorts ...

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