Now showing items 1-20 of 926

    • A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms 

      Barral Arca, Ruth; Pardo Seco, Jacobo José; Martinón Torres, Federico; Salas Ellacuriaga, Antonio (Nature Publishing Group, 2018)
      Recently, a biomarker signature consisting of 2-transcript host RNAs was proposed for discriminating bacterial from viral infections in febrile children. We evaluated the performance of this signature in a different disease ...
    • 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients 

      Sartelli, Massimo; McFarland, Lynne V.; Khanna, Sahil; Furuya Kanamori, Luis; Abuzeid, Nadir; Abu-Zizan, Fikri M.; Ansaloni, Luca; Agustin, Goran; Bala, Miklosh; Ben-Ishay, Offir; Biffl, Walter L.; Brecher, Stephen M.; Camacho Ortiz, Adrián; Caínzos Fernández, Miguel Ángel; Chan, Shirley; Cherry-Bukowiec, Jill R.; Clanton, Jesse; Coccolini, Federico; Cocuz, María E.; Coimbra, Raúl; Cortese, Francesco; Cui, Yunfeng; Czepiel, Jacek; Demetrashvili, Zaza; Di Carlo, Isidoro; Di Saverio, Salomone; Dumitru, Irina M.; Eckmann, Christian; Eiland, Edward H.; Forrester, Joseph D.; Fraga, Gustavo P.; Frossard, Jean L.; Fry, Donald E.; Galeiras, Rita; Ghnnam, Wagih; Gomes, Carlos A.; Griffiths, Ewen A.; Guirao, Xavier; Ahmed, Mohamed H.; Herzog, Torsten; Kim, Jae II; Iqbal, Tariq; Isik, Arda; Itani, Kamal M.F.; Labricciosa, Francesco M.; Lee, Yeong Y.; Juang, Paul; Karamarkovic, Aleksandar; Kim, Peter K.; Kluger, Yoram; Leppaniemi, Ari; Lohsiriwat, Varut; Machain, Gustavo M.; Marwah, Sanjay; Mazuski, John E.; Metan, Gokhan; Moore, Ernest E.; Moore, Frederick A.; Ordoñez, Carlos A.; Pagani, Leonardo; Petrosillo, Nicola; Portela, Francisco; Rasa, Kemal; Rems, Miran; Sakakushev, Boris E.; Segovia-Lohse, Helmut; Sganga, Gabriele; Shelat, Vishal G.; Spigaglia, Patrizia; Tattevin, Pierre; Tranà, Cristian; Urbánek, Libor; Ulrych, Jan; Viale, Pierluigi; Catena, Fausto; Di Bella, Stefano (BMC, 2019)
      In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and severity in many countries worldwide. The increase in CDI incidence has been particularly apparent among surgical patients. ...
    • 26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines 

      Seoane Ruzo, Samuel; Álvarez Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro Saavedra, Miguel Anxo; Mouriño Mosquera, Antonio; Pérez Fernández, Román (MDPI, 2013)
      It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
    • 3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology 

      Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2019)
      [ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the ...
    • 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients 

      Awad, Atheer; Yao, Aliya; Trenfield, Sarah J.; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2020)
      Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating ...
    • 3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease 

      Seoane Viaño, Iria; Gómez Lado, Noemí; Lázare Iglesias, Héctor; García Otero, Xurxo; Antúnez López, José Ramón; Ruibal Morell, Álvaro; Varela Correa, Juan Jesús; Aguiar Fernández, Pablo; Basit, Abdul W.; Otero Espinar, Francisco Javier; González Barcia, Miguel; Goyanes Goyanes, Álvaro; Luzardo Álvarez, Asteria María; Fernández Ferreiro, Anxo (MDPI, 2020)
      The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel ...
    • 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method 

      Robles Martínez, Pamela; Xu, Xiaoyan; Trenfield, Sarah J.; Awad, Atheer; Goyanes Goyanes, Álvaro; Telford, Richard; Basit, Abdul W.; Gaisford, Simon (MDPI, 2019)
      Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...
    • 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects 

      Pilar Olaya, María del; Vergel, Nadezdha Esperanza; López, Jose Luis; Viña Castelao, María Dolores (Universidade de São Paulo, 2020)
      Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new ...
    • ABCDE approach to victims by lifeguards: How do they manage a critical patient? : A cross sectional simulation study 

      Fernández Méndez, Felipe; Otero Agra, Martín; Abelairas Gómez, Cristian; Sáez Gallego, Nieves María; Rodríguez Núñez, Antonio; Barcala Furelos, Roberto (PLOS, 2019)
      Introduction: Decision-making in emergencies is a multifactorial process based on the rescuer, patient, setting and resources. The eye-tracking system is a proven method for assessing decision-making processes that have ...
    • Actinic Cheilitis prevalence and risk factors: a cross-sectional, multicentre study in a population aged 45 years and over in north-west Spain 

      Rodríguez Blanco, Isabel; Flórez, Ángeles; Paredes Suárez, Carmen; Rodríguez Lojo, Romina; González Vilas, Daniel; Ramírez Santos, Aquilina; Paradela, Sabela; Suárez Conde, Ignacio; Pereiro Ferreirós, Manuel (Society for Publication of Acta Dermato-Venereologica, 2018)
      Actinic cheilitis is thought to be a premalignant lesion or a superficial squamous cell carcinoma. The prevalence of actinic cheilitis in Europe is unknown. The aim of this study was to determine the prevalence of actinic ...
    • Actinic cheilitis: analysis of clinical subtypes, risk factors and associated signs of actinic damage 

      Rodríguez Blanco, Isabel; Flórez Menéndez, María Ángeles; Paredes Suárez, Carmen; Rodríguez Lojo, Romina; González Vilas, Daniel; Ramírez Santos, Aquilina; Paradela, Sabela; Suárez Conde, Ignacio; Pereiro Ferreirós, Manuel (Acta Dermato-Venereologica, 2019)
      Actinic cheilitis (AC) is a common condition that mainly involves the lower lip, which is associated with chronic exposure to ultraviolet (UV) radiation. AC is considered a precursor of malignancy (1), but the rate of ...
    • Action monitoring: correct and erroneous decisions are reflected in event-related potentials in humans 

      Padrón Rodríguez, Isabel; Pardo Vázquez, José Luis; Seoane, Ignacio; Fernández Rey, José; Acuña Castroviejo, Carlos (2014-06-27)
      The main objective of this study is to understand the functional meaning of the error-related components. We have recorded the ERPs while human subjects performed in a perceptual length discrimination task (LDT) in which ...
    • Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis 

      Saulyte, Jurgita; Regueira Méndez, Carlos Manuel Pastor; Montes Martínez, Agustín; Khudyakov, Polyna; Takkouche, Bahi (PLOS, 2014)
      Background: Allergic rhinitis, allergic dermatitis, and food allergy are extremely common diseases, especially among children, and are frequently associated to each other and to asthma. Smoking is a potential risk factor ...
    • Acumulación de selenio en setas silvestres comestibles: captación y toxicidad Selenium accumulation in wild edible mushrooms: uptake and toxicity 

      Melgar Riol, María Julia; Alonso Díaz, Julián; García Fernández, María Ángeles (Taylor & Francis, 2009)
      Los hongos acumulan selenio, metal considerado nutricionalmente oligoelemento, pero nocivo para la salud del consumidor en dosis excesivas. Se estudió el contenido de selenio en setas silvestres comestibles, teniendo en ...
    • Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX 

      Fernández Ferreiro, Sara; Carrera González, María Cristina; Vilariño del Río, Natalia; Louzao Ojeda, María Carmen; Santamarina Pernas, Germán; González Cantalapiedra, Antonio; Botana López, Luis Miguel (MDPI, 2015)
      Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins ...
    • Acute muscle fatigue and CPR quality assisted by visual feedback devices: A randomized-crossover simulation trial 

      Abelairas Gómez, Cristian; Rey, Ezequiel; González Salvado, Violeta; Mecías Calvo, Marcos; Rodríguez Ruiz, Emilio; Rodríguez Núñez, Antonio (PLOS, 2018-09-19)
      Objective: To analyse the acute muscular fatigue (AMF) in triceps brachii and rectus abdominis during compression-only and standard cardiopulmonary resuscitation (CPR) performed by certified basic life support providers. ...
    • Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods ...
    • Acyl homoserine lactone-mediated quorum sensing in the oral cavity: a paradigm revisited 

      Muras Mora, Andrea; Otero Casal, María de la Paz; Blanc, Vanessa; Otero Casal, Ana María (Nature Publishing Group, 2020)
      Acyl homoserine lactones (AHLs), the quorum sensing (QS) signals produced by Gram-negative bacteria, are currently considered to play a minor role in the development of oral biofilm since their production by oral pathogens ...
    • Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging 

      Vilas Martínez, Jéssica María; Carneiro Freire, María del Carmen; Silva Álvarez, Sabela da; Ferreirós López, Alba; González, Patricia; Gómez, María; Ortega, Sagrario; Serrano, Manuel; García-Caballero Parada, Tomás; González Barcia, Luis Miguel; Vidal Figueroa, Anxo; Collado, Manuel (Wiley, 2018-08-20)
      Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is ...





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