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Mitochondrial Echoes of First Settlement and Genetic Continuity in El Salvador
(Plos, 2009)
Background: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in
the distribution and patterns of variability all around the double American continent. However, the ...
Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula
(Springer Nature, 2019)
The Iberian Peninsula is linguistically diverse and has a complex demographic history, including a centuries-long period of Muslim rule. Here, we study the fine-scale genetic structure of its population, and the genetic ...
Ancestry Analysis in the 11-M Madrid Bomb Attack Investigation
(PLOS, 2009)
The 11-M Madrid commuter train bombings of 2004 constituted the second biggest terrorist attack to occur in Europe after
Lockerbie, while the subsequent investigation became the most complex and wide-ranging forensic case ...
New Population and Phylogenetic Features of the Internal Variation within Mitochondrial DNA Macro-Haplogroup R0
(PLOS, 2009)
Background: R0 embraces the most common mitochondrial DNA (mtDNA) lineage in West Eurasia, namely, haplogroup H
(,40%). R0 sub-lineages are badly defined in the control region and therefore, the analysis of diagnostic ...
Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort
(Plos, 2010)
Background: Colorectal cancer (CRC) is considered a complex disease, and thus the majority of the genetic susceptibility is
thought to lie in the form of low-penetrance variants following a polygenic model of inheritance. ...
Early colorectal cancers provide new evidence for a Lynch Syndrome-to-CMMRD Phenotypic Continuum
(MDPI, 2019)
Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by heterozygous mutations in the mismatch repair (MMR) genes. Biallelic mutations in these genes lead however, to constitutive ...
High Mitochondrial DNA Stability in B-Cell Chronic Lymphocytic Leukemia
(PLOS, 2009)
Background: Chronic Lymphocytic Leukemia (CLL) leads to progressive accumulation of lymphocytes in the blood, bone
marrow, and lymphatic tissues. Previous findings have suggested that the mtDNA could play an important ...
Beyond the CSI effect the keys to good forensicgenetics communication
(Universitat de València, 2019)
Forensic genetics brings together all the genetic knowledge required to solve specific legal problems. In recent decades new techniques have shown the potential of DNA as a profiling system. These advances have arrived ...
In situ characterization of stem cells-like biomarkers in meningiomas
(BMC, 2018)
Background: Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Suc‑cessful therapies developed for inoperable, recurrent, or metastatic tumors must target these cells and restrict ...
A new panel of SNPs to assess thyroid carcinoma risk: a pilot study in a Brazilian admixture population
(BMC, 2017)
Background: Thyroid cancer is a common malignant disease of the endocrine system with increasing incidence rates over the last few decades. In this study, we sought to analyze the possible association of 45 single nucleotide ...