Now showing items 24-43 of 71

    • Genetic diferentiation of a critically endangered population of the limpet Patella candei candei d’Orbigny, 1840, in the Canary Islands 

      Quinteiro Vázquez, Javier; González-Lorenzo, Gustavo; Hernández Reyes, Dailos; Quinteiro, Lara; Herrera Pérez, Rogelio; Martínez Barrio, Juan; González Ramos, Antonio Juan; Rey Méndez, Manuel; González Henríquez, Nieves (Springer, 2022)
      The adoption of measures to protect the viability of threatened populations should be supported by empirical data identifying appropriate conservation units and management strategies. The global population of the majorera ...
    • High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers 

      Ceballos Guzmán, Manuel; Cedrún-Morales, Manuela; Rodríguez Pérez, Manuel; Funes-Hernando, Samuel; Vila Fungueiriño, José Manuel; Zampini, Giulia; Polo Tobajas, Ester; Pino, Pablo del; Pelaz García, Beatriz (Royal Society of Chemistry, 2022)
      The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of ...
    • IC-Tagging and Protein Relocation to ARV muNS Inclusions: A Method to Study Protein-Protein Interactions in the Cytoplasm or Nucleus of Living Cells 

      Brandariz Núñez, Alberto; Menaya Vargas, Rebeca; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (PLOS, 2010)
      Background: Characterization of protein-protein interactions is essential for understanding cellular functions. Although there are many published methods to analyze protein-protein interactions, most of them present serious ...
    • IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen 

      Barreiro Piñeiro, Natalia; Lostalé Seijo, Irene; Varela Calviño, Rubén; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (Springer Nature, 2018)
      We have previously developed a methodology to produce protein microspheres (MS) that can be loaded with proteins of interest in living cells through their C or N-terminal tagging with the so-called IC-Tag. The IC-Tagging ...
    • Immunohistochemical expression of E–cadherin in different tissues of the teleost fish Scophthalmus maximus 

      Ronza, Paolo; Villamarín Cid, José Antonio; Méndez, Lucía; Gómez Pardo, María Belén; Bermúdez Pose, Roberto; Quiroga Berdeal, María Isabel (Elsevier, 2019)
      E–cadherin is an evolutionary conserved protein, whose main role as the principal component of adherens junctions is supporting epithelial cell–cell adhesion. It is an essential molecule for the maintenance of the epithelial ...
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function 

      Lima, Nátalia da Silva; Fernández Fondevila; Nóvoa Deaño, Eva María; Buqué, Xabier; Mercado Gómez, María; Gallet, Sarah; González Rellán, María Jesús; Fernández Paz, Uxía; Loyens, Anne; García Vence, María; Chantada Vázquez, María del Pilar; Bravo López, Susana Belén; Marañón Barnusell, Patricia; Senra Viñas, Ana; Escudero Pérez, Adriana; Leiva Arjona, Magdalena; Guallar Artal, Diana; Fidalgo Pérez, Miguel Ángel; Gomes, Pedro; Claret, Marc; Sabio Buzo, Guadalupe; Varela Rey, Marta; Cardoso Delgado, Teresa; MONTERO VALLEJO, ROCIO; Ampuero, Javier; López Pérez, Miguel Antonio; Diéguez González, Carlos; Herrero, Laura; Serra Cucurull, Dolors; Schwaninger, Markus; Prevot, Vincent; Gallego-Durán, Rocío; Romero-Gómez, Manuel; IRUZUBIETA, PAULA; Crespo García, Javier; Martinez Chantar, Maria Luz; García Monzón, Carmelo; González-Rodríguez, Águeda; Aspichueta, Patricia; Nogueiras Pozo, Rubén (Elsevier, 2021)
      Non-alcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, ...
    • Insights into substrate binding and catalysis in bacterial type I dehydroquinase 

      Maneiro Rey, María; Peón López, Antonio; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Portland Press, 2014-09-15)
      Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ...
    • Interferon induction by avian reovirus 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2016-01)
      We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ...
    • Invasion of the dark false mussel in shrimp farms in Venezuela: species identification and genetic analysis 

      Lodeiros, Cesar; González Henríquez, Nieves; Cuéllar Anjel, Jorge; Hernández Reyes, Dailos; Medina Alcaraz, Carolina; Quinteiro Vázquez, Javier; Rey Méndez, Manuel (Regional Euro-Asian Biological Invasions Centre (REABIC), 2019)
      An inspection was carried out at shrimp farms located South West of Lake Maracaibo (Zulia State, Venezuela), with high incidences of mussel bivalve. Morphological and genetic analysis helped to identify the species as ...
    • Irreversible covalent modification of type I dehydroquinase with a stable Schiff base 

      Tizón, Lorena; Maneiro Rey, María; Peón López, Antonio; Otero Casas, José Manuel; Lence Quintana, Emilio José; Poza, Sergio; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2015)
      The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, is investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics of the ...
    • Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids 

      Lence Quintana, Emilio José; Tizón, Lorena; Otero Casas, José Manuel; Peón López, Antonio; Prazeres, Verónica F. V.; Llamas Saiz, Antonio Luis; Fox, Gavin V.; Raaij, Mark J. van; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing or electron-donating groups in type II dehydroquinase enzyme ...
    • Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases 

      Coderch, Claire; Lence Quintana, Emilio José; Peón López, Antonio; Lamb, Heather; Hawkins, Alastair R.; Gago, Federico; González Bello, Concepción (Portland Press, 2014-03-15)
      DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target for the development ...
    • Microspheres-prime/rMVA-boost vaccination enhances humoral and cellular immune response in IFNAR(−/−) mice conferring protection against serotypes 1 and 4 of bluetongue virus 

      Marín López, Alejandro; Calvo Pinilla, Eva; Barriales, Diego; Lorenzo, Gema; Benavente Martínez, Francisco Javier; Brun, Alejandro; Martínez Costas, José Manuel; Ortego, Javier (Elsevier, 2017-06)
      Bluetongue virus (BTV) is the causative agent of bluetongue disease (BT), which affects domestic and wild ruminants. At the present, 27 different serotypes have been documented. Vaccination has been demonstrated as one of ...
    • MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2014)
      We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ...
    • Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover 

      Blanco Rodríguez, Beatriz; Prado, Verónica; Lence Quintana, Emilio José; Otero Casas, José Manuel; García Doval, Carmela; Raaij, Mark J. van; Llamas Saiz, Antonio Luis; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive target for the development of new antibiotics. The key interactions ...
    • Naturally presented HLA class I–restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes 

      Calviño Sampedro, Cristina; Gómez Touriño, Iria María; Cordero Santamaría, Óscar Javier; Reche Gallardo, Pedro Antonio; Gómez Perosanz, Marta; Rodríguez Díaz, Miguel Ángel; Sueiro, Aurelio M.; Viñuela Roldán, Juan Evaristo; Varela Calviño, Rubén (Federation of American Societies for Experimental Biology, 2019)
      Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells by the immune system, and CD8+ T lymphocytes are critical actors in this autoimmune response. Pancreatic islets are surrounded by a mesh of nervous ...
    • Obesity Does Not Increase the Risk of Asthma Readmissions 

      González Barcala, Francisco Javier; Nieto Fontarigo, Juan José; Lourido Cebreiro, Tamara; Rodríguez García, Carlota; San José Capilla, María Esther; Carreira Villamor, José Martín; Calvo Álvarez, Uxío; Cruz, María Jesús; Facal Mayo, David; García Sanz, María Teresa; Valdés Cuadrado, Luis Guillermo; Salgado Castro, Francisco Javier (MDPI, 2020)
      The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively ...
    • Oral hygiene might prevent cancer 

      Cordero Santamaría, Óscar Javier; Varela Calviño, Rubén (Elsevier, 2018)
      Many evidences support that species from the Human Oral Microbiome Database such as Fusobacterium nucleatum or Bacteroides, linked previously to periodontitis and appendicitis, play a role in colorectal cancer (CRC), ...





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