Now showing items 36-55 of 71

    • Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids 

      Lence Quintana, Emilio José; Tizón, Lorena; Otero Casas, José Manuel; Peón López, Antonio; Prazeres, Verónica F. V.; Llamas Saiz, Antonio Luis; Fox, Gavin V.; Raaij, Mark J. van; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing or electron-donating groups in type II dehydroquinase enzyme ...
    • Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases 

      Coderch, Claire; Lence Quintana, Emilio José; Peón López, Antonio; Lamb, Heather; Hawkins, Alastair R.; Gago, Federico; González Bello, Concepción (Portland Press, 2014-03-15)
      DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target for the development ...
    • Microspheres-prime/rMVA-boost vaccination enhances humoral and cellular immune response in IFNAR(−/−) mice conferring protection against serotypes 1 and 4 of bluetongue virus 

      Marín López, Alejandro; Calvo Pinilla, Eva; Barriales, Diego; Lorenzo, Gema; Benavente Martínez, Francisco Javier; Brun, Alejandro; Martínez Costas, José Manuel; Ortego, Javier (Elsevier, 2017-06)
      Bluetongue virus (BTV) is the causative agent of bluetongue disease (BT), which affects domestic and wild ruminants. At the present, 27 different serotypes have been documented. Vaccination has been demonstrated as one of ...
    • MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2014)
      We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ...
    • Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover 

      Blanco Rodríguez, Beatriz; Prado, Verónica; Lence Quintana, Emilio José; Otero Casas, José Manuel; García Doval, Carmela; Raaij, Mark J. van; Llamas Saiz, Antonio Luis; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive target for the development of new antibiotics. The key interactions ...
    • Naturally presented HLA class I–restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes 

      Calviño Sampedro, Cristina; Gómez Touriño, Iria María; Cordero Santamaría, Óscar Javier; Reche Gallardo, Pedro Antonio; Gómez Perosanz, Marta; Rodríguez Díaz, Miguel Ángel; Sueiro, Aurelio M.; Viñuela Roldán, Juan Evaristo; Varela Calviño, Rubén (Federation of American Societies for Experimental Biology, 2019)
      Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells by the immune system, and CD8+ T lymphocytes are critical actors in this autoimmune response. Pancreatic islets are surrounded by a mesh of nervous ...
    • Obesity Does Not Increase the Risk of Asthma Readmissions 

      González Barcala, Francisco Javier; Nieto Fontarigo, Juan José; Lourido Cebreiro, Tamara; Rodríguez García, Carlota; San José Capilla, María Esther; Carreira Villamor, José Martín; Calvo Álvarez, Uxío; Cruz, María Jesús; Facal Mayo, David; García Sanz, María Teresa; Valdés Cuadrado, Luis Guillermo; Salgado Castro, Francisco Javier (MDPI, 2020)
      The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively ...
    • Oral hygiene might prevent cancer 

      Cordero Santamaría, Óscar Javier; Varela Calviño, Rubén (Elsevier, 2018)
      Many evidences support that species from the Human Oral Microbiome Database such as Fusobacterium nucleatum or Bacteroides, linked previously to periodontitis and appendicitis, play a role in colorectal cancer (CRC), ...
    • Phylogeography of the insular populations of common octopus, Octopus vulgaris Cuvier, 1797, in the Atlantic Macaronesia 

      Quinteiro Vázquez, Javier; Rodríguez Castro, Jorge; Rey Méndez, Manuel; González Henríquez, Nieves (Plos, 2020)
      Exploited, understudied populations of the common octopus, Octopus vulgaris Cuvier, 1797, occur in the northeastern Atlantic (NEA) throughout Macaronesia, comprising the Azores, Madeira and Canaries, and also the Cabo Verde ...
    • Postoperative serum levels of sCD26 for surveillance in colorectal cancer patients 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Cordero Santamaría, Óscar Javier; Vázquez Tuñas, Lidia; Ayude, Daniel; Rodríguez Berrocal, Francisco Javier; Páez de la Cadena, María (PLOS, 2014)
      One of the main aims of the follow-up after curative resection of colorectal cancer is the early detection and treatment of tumor recurrence. We previously demonstrated decreased preoperative soluble CD26 (sCD26) levels ...
    • Postprandial glycemic response in a non-diabetic adult population: the effect of nutrients is different between men and women 

      González Rodríguez, María; Pazos Couselo, Marcos; García López, José Manuel; Rodríguez-Segade Villamarín, Santiago; Rodríguez García, Javier; Túñez Bastida, Carmen; Gude Sampedro, Francisco (BMC, 2019)
      Background: There is a growing interest in the pathopysiological consequences of postprandial hyperglycemia. It is well known that in diabetic patients 2 h plasma glucose is a better risk predictor for coronary heart ...
    • Programmed stereoselective assembly of DNA-binding helical metallopeptides 

      Gamba, Ilaria; Rama, Gustavo; Ortega-Carrasco, Elisabeth; Maréchal, Jean-Didier; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2014)
      A flexible and versatile synthetic approach for the construction of water-stable DNA-binding chiral peptide helicates based on the solid phase peptide synthesis (SPPS) methodology is reported
    • Real-time investigation of dynamic protein crystallization in living cells 

      Schonherr, R.; Klinge, M.; Rudolph, J. M.; Fita, K.; Rehders, D.; Lubber, F.; Schneegans, S.; Majoul, I. V.; Duszenko, M.; Betzel, C.; Brandariz Núñez, Alberto; Martínez Costas, José Manuel; Duden, R.; Redecke, L. (AIP Publishing, 2015)
      X-ray crystallography requires sufficiently large crystals to obtain structural insights at atomic resolution, routinely obtained in vitro by time-consuming screening. Recently, successful data collection was reported from ...
    • Real-time investigation of dynamic protein crystallization in living cells 

      Schönherr, R.; Klinge, M.; Rudolph, J. M.; Fita, K.; Rehders, D.; Lübber, F.; Schnnegans, S.; Majoul, I. V.; Duszenko, M.; Betzel, C.; Brandariz Núñez, Alberto; Martínez Costas, José Manuel; Duden, R.; Redecke, L. (AIP Publishing, 2015)
      X-ray crystallography requires sufficiently large crystals to obtain structural insights at atomic resolution, routinely obtained in vitro by time-consuming screening. Recently, successful data collection was reported from ...
    • Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (American Society for Microbiology, 2016)
      We have previously shown that the replication of avian reovirus (ARV) in chicken cells is much more resistant to interferon (IFN) than the replication of vesicular stomatitis virus (VSV) or vaccinia virus (VV). In this ...
    • RNA-Seq Transcriptome Profiling of the Queen Scallop (Aequipecten opercularis) Digestive Gland after Exposure to Domoic Acid-Producing Pseudo-nitzschia 

      Ventoso Osorio, Pablo; Pazos Castelos, Antonio Juan; Pérez-Parallé Mera, María Luz; Blanco Pérez, Juan Carlos; Triviño, Juan Carlos; Sánchez López, José Luís (MDPI, 2019)
      Some species of the genus Pseudo-nitzschia produce the toxin domoic acid, which causes amnesic shellfish poisoning (ASP). Given that bivalve mollusks are filter feeders, they can accumulate these toxins in their tissues. ...
    • Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif 

      PISANI, Leonardo; Farina, Roberta; Soto-Otero, Ramón; DENORA, Nunzio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; CATTO, Marco; Carotti, Angelo (MDPI, 2016-03-17)
      The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates ...
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo 

      Matić, Ivana Z.; Đorđić, Marija; Grozdanić, Nađa; Damjanović, Ana; Kolundžija, Branka; Erić Nikolić, Aleksandra; Džodić, Radan; Šašić, Miomir; Nikolić, Srđan; Dobrosavljević, Danijela; Rašković, Sanvila; Andrejević, Slađana; Gavrilović, Dušica; Cordero Santamaría, Óscar Javier; Juranić, Zorica D. (BMC, 2012)
      Background: Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in regulation of malignant transformation, promotion and further progression of cancer, exerting tumor-suppressing or even completely opposite ...
    • Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Rodríguez Berrocal, Francisco Javier; Cordero Santamaría, Óscar Javier; Martínez Ares, David; Páez de la Cadena, María (BMC, 2010)
      Background: Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate ...





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