Now showing items 42-61 of 71

    • Obesity Does Not Increase the Risk of Asthma Readmissions 

      González Barcala, Francisco Javier; Nieto Fontarigo, Juan José; Lourido Cebreiro, Tamara; Rodríguez García, Carlota; San José Capilla, María Esther; Carreira Villamor, José Martín; Calvo Álvarez, Uxío; Cruz, María Jesús; Facal Mayo, David; García Sanz, María Teresa; Valdés Cuadrado, Luis Guillermo; Salgado Castro, Francisco Javier (MDPI, 2020)
      The relationship between obesity and asthma exacerbations is still under debate. The aim of our work is to analyse the relationship between obesity and hospital re-admissions in asthmatics. A review was retrospectively ...
    • Oral hygiene might prevent cancer 

      Cordero Santamaría, Óscar Javier; Varela Calviño, Rubén (Elsevier, 2018)
      Many evidences support that species from the Human Oral Microbiome Database such as Fusobacterium nucleatum or Bacteroides, linked previously to periodontitis and appendicitis, play a role in colorectal cancer (CRC), ...
    • Phylogeography of the insular populations of common octopus, Octopus vulgaris Cuvier, 1797, in the Atlantic Macaronesia 

      Quinteiro Vázquez, Javier; Rodríguez Castro, Jorge; Rey Méndez, Manuel; González Henríquez, Nieves (Plos, 2020)
      Exploited, understudied populations of the common octopus, Octopus vulgaris Cuvier, 1797, occur in the northeastern Atlantic (NEA) throughout Macaronesia, comprising the Azores, Madeira and Canaries, and also the Cabo Verde ...
    • Postoperative serum levels of sCD26 for surveillance in colorectal cancer patients 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Cordero Santamaría, Óscar Javier; Vázquez Tuñas, Lidia; Ayude, Daniel; Rodríguez Berrocal, Francisco Javier; Páez de la Cadena, María (PLOS, 2014)
      One of the main aims of the follow-up after curative resection of colorectal cancer is the early detection and treatment of tumor recurrence. We previously demonstrated decreased preoperative soluble CD26 (sCD26) levels ...
    • Postprandial glycemic response in a non-diabetic adult population: the effect of nutrients is different between men and women 

      González Rodríguez, María; Pazos Couselo, Marcos; García López, José Manuel; Rodríguez-Segade Villamarín, Santiago; Rodríguez García, Javier; Túñez Bastida, Carmen; Gude Sampedro, Francisco (BMC, 2019)
      Background: There is a growing interest in the pathopysiological consequences of postprandial hyperglycemia. It is well known that in diabetic patients 2 h plasma glucose is a better risk predictor for coronary heart ...
    • Programmed stereoselective assembly of DNA-binding helical metallopeptides 

      Gamba, Ilaria; Rama, Gustavo; Ortega-Carrasco, Elisabeth; Maréchal, Jean-Didier; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2014)
      A flexible and versatile synthetic approach for the construction of water-stable DNA-binding chiral peptide helicates based on the solid phase peptide synthesis (SPPS) methodology is reported
    • Real-time investigation of dynamic protein crystallization in living cells 

      Schonherr, R.; Klinge, M.; Rudolph, J. M.; Fita, K.; Rehders, D.; Lubber, F.; Schneegans, S.; Majoul, I. V.; Duszenko, M.; Betzel, C.; Brandariz Núñez, Alberto; Martínez Costas, José Manuel; Duden, R.; Redecke, L. (AIP Publishing, 2015)
      X-ray crystallography requires sufficiently large crystals to obtain structural insights at atomic resolution, routinely obtained in vitro by time-consuming screening. Recently, successful data collection was reported from ...
    • Real-time investigation of dynamic protein crystallization in living cells 

      Schönherr, R.; Klinge, M.; Rudolph, J. M.; Fita, K.; Rehders, D.; Lübber, F.; Schnnegans, S.; Majoul, I. V.; Duszenko, M.; Betzel, C.; Brandariz Núñez, Alberto; Martínez Costas, José Manuel; Duden, R.; Redecke, L. (AIP Publishing, 2015)
      X-ray crystallography requires sufficiently large crystals to obtain structural insights at atomic resolution, routinely obtained in vitro by time-consuming screening. Recently, successful data collection was reported from ...
    • Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (American Society for Microbiology, 2016)
      We have previously shown that the replication of avian reovirus (ARV) in chicken cells is much more resistant to interferon (IFN) than the replication of vesicular stomatitis virus (VSV) or vaccinia virus (VV). In this ...
    • RNA-Seq Transcriptome Profiling of the Queen Scallop (Aequipecten opercularis) Digestive Gland after Exposure to Domoic Acid-Producing Pseudo-nitzschia 

      Ventoso Osorio, Pablo; Pazos Castelos, Antonio Juan; Pérez-Parallé Mera, María Luz; Blanco Pérez, Juan Carlos; Triviño, Juan Carlos; Sánchez López, José Luís (MDPI, 2019)
      Some species of the genus Pseudo-nitzschia produce the toxin domoic acid, which causes amnesic shellfish poisoning (ASP). Given that bivalve mollusks are filter feeders, they can accumulate these toxins in their tissues. ...
    • Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif 

      PISANI, Leonardo; Farina, Roberta; Soto-Otero, Ramón; DENORA, Nunzio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; CATTO, Marco; Carotti, Angelo (MDPI, 2016-03-17)
      The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates ...
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo 

      Matić, Ivana Z.; Đorđić, Marija; Grozdanić, Nađa; Damjanović, Ana; Kolundžija, Branka; Erić Nikolić, Aleksandra; Džodić, Radan; Šašić, Miomir; Nikolić, Srđan; Dobrosavljević, Danijela; Rašković, Sanvila; Andrejević, Slađana; Gavrilović, Dušica; Cordero Santamaría, Óscar Javier; Juranić, Zorica D. (BMC, 2012)
      Background: Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in regulation of malignant transformation, promotion and further progression of cancer, exerting tumor-suppressing or even completely opposite ...
    • Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Rodríguez Berrocal, Francisco Javier; Cordero Santamaría, Óscar Javier; Martínez Ares, David; Páez de la Cadena, María (BMC, 2010)
      Background: Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate ...
    • Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions 

      Silva Candal, Andrés da; Brown, Tyler D.; Krishnan, Vinu; López Loureiro, José Ignacio; Ávila Gómez, Paulo; Pusuluri, Anusha; Pérez Díaz, Amparo; Correa Paz, Clara; Hervella Lorenzo, Pablo; Castillo Sánchez, José Antonio; Mitragotri, Samir; Campos Pérez, Francisco (Elsevier, 2019)
      Endothelial cells represent the first biological barrier for compounds, including nanoparticles, administered via the intravascular route. In the case of ischemic stroke and other vascular diseases, the endothelium ...
    • Soluble CD26 Levels and Its Association to Epidemiologic Parameters in a Sample Population 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Cordero Santamaría, Óscar Javier; Rodríguez Berrocal, Francisco Javier; Ayude, Daniel; Rivas Hervada, Francisco J.; Páez de la Cadena, María (Hindawi, 2009)
      Introduction: Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration ...
    • Spectroscopic characterization of mitochondrial G-quadruplexes 

      Illodo, Sara; Pérez González, Cibrán; Barcia, Ramiro; Rodriguez-Prieto, Flor ; Al-Soufi, Wajih; Novo Rodríguez, Mercedes (MDPI, 2022)
      Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures ...
    • Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis 

      Varela Calviño, Rubén; Cordero Santamaría, Óscar Javier (Baishideng Publishing, 2015)
      An important percentage of colorectal cancer (CRC) patients will develop metastasis, mainly in the liver, even after a successful curative resection. This leads to a very high mortality rate if metastasis is not detected ...
    • Study of plasma anti-CD26 autoantibody levels in a cohort of treatment-naïve early arthritis patients 

      Cordero Santamaría, Óscar Javier; Viéitez González, Irene; Altabás González, Irene; Nuño Nuño, Laura; Villalba Yllán, Alejandro; Novella Navarro , Marta; Peiteado López, Diana; Miranda-Carús, María-Eugenia; Balsa Criado, Alejandro; Varela Calviño, Rubén; Gómez Touriño, Iria María; Pego Reigosa, José María (Springer, 2022)
      In rheumatoid arthritis (RA), the identifcation of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We ...
    • Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets 

      Vázquez Iglesias, Lorena; Barcia Castro, Leticia; Rodríguez Quiroga, Marta; Páez de la Cadena, María; Rodríguez Berrocal, Francisco Javier; Cordero Santamaría, Óscar Javier (The Company of Biologists, 2019)
      Taking advantage of eight established cell lines from colorectal cancer patients at different stages of the disease and the fact that all of them could form spheres, cell surface biomarkers of cancer stem cells and ...





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