Now showing items 52-71 of 71

    • Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif 

      PISANI, Leonardo; Farina, Roberta; Soto-Otero, Ramón; DENORA, Nunzio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; CATTO, Marco; Carotti, Angelo (MDPI, 2016-03-17)
      The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates ...
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo 

      Matić, Ivana Z.; Đorđić, Marija; Grozdanić, Nađa; Damjanović, Ana; Kolundžija, Branka; Erić Nikolić, Aleksandra; Džodić, Radan; Šašić, Miomir; Nikolić, Srđan; Dobrosavljević, Danijela; Rašković, Sanvila; Andrejević, Slađana; Gavrilović, Dušica; Cordero Santamaría, Óscar Javier; Juranić, Zorica D. (BMC, 2012)
      Background: Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in regulation of malignant transformation, promotion and further progression of cancer, exerting tumor-suppressing or even completely opposite ...
    • Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Rodríguez Berrocal, Francisco Javier; Cordero Santamaría, Óscar Javier; Martínez Ares, David; Páez de la Cadena, María (BMC, 2010)
      Background: Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate ...
    • Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions 

      Silva Candal, Andrés da; Brown, Tyler D.; Krishnan, Vinu; López Loureiro, José Ignacio; Ávila Gómez, Paulo; Pusuluri, Anusha; Pérez Díaz, Amparo; Correa Paz, Clara; Hervella Lorenzo, Pablo; Castillo Sánchez, José Antonio; Mitragotri, Samir; Campos Pérez, Francisco (Elsevier, 2019)
      Endothelial cells represent the first biological barrier for compounds, including nanoparticles, administered via the intravascular route. In the case of ischemic stroke and other vascular diseases, the endothelium ...
    • Soluble CD26 Levels and Its Association to Epidemiologic Parameters in a Sample Population 

      Chiara, Loretta De; Rodríguez Piñeiro, Ana M.; Cordero Santamaría, Óscar Javier; Rodríguez Berrocal, Francisco Javier; Ayude, Daniel; Rivas Hervada, Francisco J.; Páez de la Cadena, María (Hindawi, 2009)
      Introduction: Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration ...
    • Spectroscopic characterization of mitochondrial G-quadruplexes 

      Illodo, Sara; Pérez González, Cibrán; Barcia, Ramiro; Rodriguez-Prieto, Flor ; Al-Soufi, Wajih; Novo Rodríguez, Mercedes (MDPI, 2022)
      Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures ...
    • Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis 

      Varela Calviño, Rubén; Cordero Santamaría, Óscar Javier (Baishideng Publishing, 2015)
      An important percentage of colorectal cancer (CRC) patients will develop metastasis, mainly in the liver, even after a successful curative resection. This leads to a very high mortality rate if metastasis is not detected ...
    • Study of plasma anti-CD26 autoantibody levels in a cohort of treatment-naïve early arthritis patients 

      Cordero Santamaría, Óscar Javier; Viéitez González, Irene; Altabás González, Irene; Nuño Nuño, Laura; Villalba Yllán, Alejandro; Novella Navarro , Marta; Peiteado López, Diana; Miranda-Carús, María-Eugenia; Balsa Criado, Alejandro; Varela Calviño, Rubén; Gómez Touriño, Iria María; Pego Reigosa, José María (Springer, 2022)
      In rheumatoid arthritis (RA), the identifcation of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We ...
    • Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets 

      Vázquez Iglesias, Lorena; Barcia Castro, Leticia; Rodríguez Quiroga, Marta; Páez de la Cadena, María; Rodríguez Berrocal, Francisco Javier; Cordero Santamaría, Óscar Javier (The Company of Biologists, 2019)
      Taking advantage of eight established cell lines from colorectal cancer patients at different stages of the disease and the fact that all of them could form spheres, cell surface biomarkers of cancer stem cells and ...
    • The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution 

      Mosquera Orgueira, Adrián; Alonso Vence, Natalia; Díaz Arias, José Ángel; Antelo Rodríguez, Beatriz; Díaz Varela, Nicolás Antonio; Pérez Encinas, Manuel Mateo; Allegue Toscano, Catarina; Goiricelaya Seco, Elena María; Carracedo Álvarez, Ángel María; Bello López, José Luis (BMC, 2019)
      Background Chronic Lymphocytic Leukemia (CLL) is the most frequent lymphoproliferative disorder in western countries and is characterized by a remarkable clinical heterogeneity. During the last decade, multiple genomic ...
    • The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes 

      Nieto Fontarigo, Juan José; Salgado Castro, Francisco Javier; San-José, M. E.; Cruz, M. J.; Casas-Fernández, A.; Gómez-Conde, M. J.; Valdés Cuadrado, Luis Guillermo; García González, Miguel Ángel; Arias Crespo, María Pilar; Nogueira, M.; González Barcala, Francisco Javier (Springer Nature, 2018-03-07)
      LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma. Therefore, CD14 modulation could alter the ...
    • The oxyhaemoglobin dissociation curve is generally left-shifted in COVID-19 patients at admission to hospital, and this is associated with lower mortality 

      Valle, Andrea; Rodriguez Garcia, Javier; Camiña Darriba, Manuel Felix; Rodríguez Segade, Miguel; Ortolá Devesa, Juan Bautista; Rodríguez Segade, Santiago (Wiley, 2022)
      Lung damage caused by SARS-Cov-2 virus results in marked arterial hypoxia, accompanied in many cases by hypocapnia. The literature is inconclusive as to whether these conditions induce alteration of the affinity of haemoglobin ...
    • Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes 

      Amaral, Sandra P.; Tawara, Ma’un Hasan Haroon; Fernández Villamarín, Marcos; Borrajo, Erea; Martínez Costas, José Manuel; Vidal Figueroa, Anxo; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Wiley, 2018-04-27)
      The generation of dendrimers is a powerful tool in the control of the size and biodistribution of polyion complexes (PIC). Using a combinatorial screening of six dendrimers (18–243 terminal groups) and five oppositely ...
    • A Versatile Molecular Tagging Method for Targeting Proteins to Avian Reovirus muNS Inclusions. Use in Protein Immobilization and Purification 

      Brandariz Núñez, Alberto; Menaya Vargas, Rebeca; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (PLOS, 2010)
      Background: Avian reoviruses replicate in viral factories, which are dense cytoplasmic compartments estabilished by protein-protein interactions. The non-structural protein muNS forms the factory scaffold that attracts ...
    • Virtual Reality as a Tool for Evaluation of Repetitive Rhythmic Movements in the Elderly and Parkinson's Disease Patients 

      Arias Carpintero, Pablo; Robles García, Verónica; Sanmartín Díaz, Gabriel; Flores González, Julián; Cudeiro, Javier (PLOS, 2012)
      This work presents an immersive Virtual Reality (VR) system to evaluate, and potentially treat, the alterations in rhythmic hand movements seen in Parkinson's disease (PD) and the elderly (EC), by comparison with healthy ...
    • What are the principles that govern life? 

      Gómez Márquez, Jaime José (Taylor & Francis, 2020)
      We know that living matter must behave in accordance with the universal laws of physics and chemistry. However, these laws are insufficient to explain the specific characteristics of the vital phenomenon and, therefore, ...
    • What is life? 

      Gómez Márquez, Jaime José (Springer, 2021)
      Background: Many traditional biological concepts continue to be debated by biologists, scientists and philosophers of science. The specific objective of this brief reflection is to offer an alternative vision to the ...
    • XVIII Foro dos Recursos Mariños e da Acuicultura das Rías Galegas 

      Rey Méndez, Manuel; Fernández Casal, Jacobo; Lodeiros, Cesar; Guerra Díaz, Alejandro (Asociación Foro dos Recursos Mariños e da Acuicultura das Rías Galegas, 2016)
      O XVIII Foro dos Recursos Mariños e da Acuicultura das Rías Galegas (FOROACUI), celebrouse na Illa da Toxa os días 8 e 9 de outubro de 2015. Na primeira xornada realizáronse as mesas de traballo: Marisqueo e Pesca de ...
    • YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells 

      Wang, Jia; Wu, Xingui; Wei, Chao; Huang, Xin; Ma, Qian; Huang, Xiaona; Fabiola, Francesco; Guallar Artal, Diana; Fidalgo Pérez, Miguel Ángel; Huang, Tingyuan; Peng, Di; Chen, Li; Yu, Haopeng; Li, Xingyu; Sun, Junyi; Liu, Xinyi (Cell Press, 2018)
      Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The ...





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