Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/29037
Ficheiros no ítem
Metadatos do ítem
Título: | Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome |
Autor/a: | Rial Pensado, Eva Freire Agulleiro, Óscar Ríos García, Marcos Guo, Deng Fu Contreras Jiménez, Cristina Seoane Collazo, Patricia Tovar, Sulay Nogueiras Pozo, Rubén Diéguez González, Carlos Rahmouni, Kamal López Pérez, Miguel Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Fisioloxía |
Palabras chave: | Obesity | Hypothalamus | AMPK | BAT | BMP8B | BBS1 | |
Data: | 2022 |
Editor: | Elsevier |
Cita bibliográfica: | Molecular Metabolism 59 (2022) 101465 |
Resumo: | Objective : Bone morphogenetic protein 8B (BMP8B) plays a major role in the regulation of energy homeostasis by modulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. Here, we investigated whether BMP8B's role in metabolism is affected by obesity and the possible molecular mechanisms underlying that action. Methods: Central treatments with BMP8B were performed in rats fed a standard (SD) and high-fat diet (HFD), as well as in genetically modified mice. Energy balance studies, infrared thermographic analysis of BAT and molecular analysis of the hypothalamus, BAT and WAT were carried out. Results: We show for the first time that HFD-induced obesity elicits resistance to the central actions of BMP8B on energy balance. This obesity-induced BMP8B resistance is explained by i) lack of effects on AMP-activated protein kinase (AMPK) signaling, ii) decreased BMP receptors signaling and iii) reduced expression of Bardet-Biedl Syndrome 1 (BBS1) protein, a key component of the protein complex BBSome in the ventromedial nucleus of the hypothalamus (VMH). The possible mechanistic involvement of BBS1 in this process is demonstrated by lack of a central response to BMP8B in mice carrying a single missense disease-causing mutation in the Bbs1 gene. Conclusions:Overall, our data uncover a new mechanism of central resistance to hormonal action that may be of relevance in the pathophysiology of obesity |
Versión do editor: | https://doi.org/10.1016/j.molmet.2022.101465 |
URI: | http://hdl.handle.net/10347/29037 |
DOI: | 10.1016/j.molmet.2022.101465 |
E-ISSN: | 2212-8778 |
Dereitos: | ©2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
-
- CIMUS-Artigos [249]
O ítem ten asociados os seguintes ficheiros de licenza: