Recent Submissions

  • Benzopyran-2-ones as attractive scaffold for MAO inhibitors: synthesis, biological evaluation and docking studies 

    Vázquez Rodríguez, Saleta; Matos, Maria João Correia Pinto Carvalho de; Uriarte Villares, Eugenio; Ferino, Giulio; Cadoni, Enzo; Viña Castelao, María Dolores (MDPI, 2011)
    Neurodegenerative diseases are becoming prevalent pathologies in developed societies due to increasing average of life expectancy of the population. This fact has encouraged an active research in the development of new ...
  • Synthesis of new phthalazinedione derivatives 

    Munín Doce, Javier; Quezada González, Elías Neftalí; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Viña Castelao, María Dolores (MDPI, 2011)
    In the past few decades, the synthesis of new heterocyclic compounds has been a subject of great interest due to their wide applicability. Among a large variety of heterocyclic compounds, heterocycles containing phthalazine ...
  • Synthesis and pharmacological evaluation of coumarins as new scaffold on the Parkinson´s disease 

    Matos, Maria João Correia Pinto Carvalho de; Viña Castelao, María Dolores; Janeiro, Patricia; Orallo Cambeiro, Francisco; Uriarte Villares, Eugenio; Santana Penín, María Lourdes (MDPI, 2009)
    With the aim to find out the structural features for the MAO inhibitory activity and selectivity, in the present communication we report the design, synthesis and pharmacological evaluation of a new series of 8-bromo-6-m ...
  • Design, Synthesis and Pharmacological Evaluation of New Coumarin Derivatives as Monoamine Oxidase A and B Inhibitors 

    Matos, Maria João Correia Pinto Carvalho de; Santana Penín, María Lourdes; Janeiro, Patricia; Quezada González, Elías Neftalí; Uriarte Villares, Eugenio; González Díaz, Humberto; Viña Castelao, María Dolores; Orallo Cambeiro, Francisco (MDPI, 2008)
    With the aim to find out the structural features for the MAO inhibitory activity and selectivity, in the present communication we report the design, synthesis and pharmacological evaluation of a new series of coumarin ...
  • Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders 

    Quezada González, Elías Neftalí; Rodríguez Enríquez, Fernanda; Laguna Francia, María de los Reyes; Cutrín Gómez, Elena; Otero Espinar, Francisco Javier; Uriarte Villares, Eugenio; Viña Castelao, María Dolores (MDPI, 2021)
    Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these diseases. Over the last decade, many innovative curcumin-based ...

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