Now showing items 95-114 of 223

    • Heart Alterations after Domoic Acid Administration in Rats 

      Crespo Vieira, Andrés; Cifuentes Martínez, José Manuel; Bermúdez Pose, Roberto; Fernández Ferreiro, Sara; Román Castro, Albina; Botana López, Luis Miguel (MDPI AG, 2016-03-10)
      Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries ...
    • Hesperidin as a neuroprotective agent: a review of animal and clinical evidence 

      Hajialyani, Marziyeh; Farzaei, Mohammad Hosein; Echeverría, Javier; Nabavi, Seyed Mohammad; Uriarte Villares, Eugenio; Sobarzo Sánchez, Eduardo Marcelo (MDPI, 2019)
      Neuroprotection is the preservation of function and networks of neural tissues from damages caused by various agents, as well as neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Huntington’s diseases, and ...
    • High serum cyclophilin C levels as a risk factor marker for coronary artery disease 

      Alfonso Rancaño, María Amparo; Bayón Lorenzo, Jeremías; Gegunde Mosquera, Sandra; Alonso López, Eva; Alvariño Romero, Rebeca; Santás Álvarez, Melisa; Testa Fernández, Ana; Ríos Vázquez, Ramón; González Juanatey, Carlos; Botana López, Luis Miguel (Nature Publishing Group, 2019)
      Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are ...
    • How Safe Is Safe for Marine Toxins Monitoring? 

      Botana López, Luis Miguel; Alfonso Rancaño, María Amparo; Rodríguez Filgueiras, Inés; Botana López, Ana María; Louzao Ojeda, María Carmen; Rodríguez Vieytes, María Mercedes (MDPI AG, 2016-07-06)
      Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were ...
    • Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing 

      Amato, Giovanni; Grimaudo, Maria Aurora; Álvarez Lorenzo, Carmen Isabel; Concheiro Nine, Ángel Joaquín; Carbone, Claudia; Bonaccorso, Angela; Puglisi, Giovanni; Musumeci, Teresa (MDPI, 2021)
      Physiological wound healing process can be delayed in the presence of certain pathologies, such as diabetes or cancer. In this perspective, the aim of this study was to design a new nanogel platform of hyaluronan, poly-L-lysine ...
    • Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications 

      Velasco Rodríguez, Brenda; Diaz Vidal, Tania; Rosales Rivera, Luis Carlos; García González, Carlos Alberto; Álvarez Lorenzo, Carmen Isabel; Al-Modlej, Abeer; Domínguez Arca, Vicente; Prieto Estévez, Gerardo; Barbosa Fernández, Silvia; Soltero Martinez, José Félix Armando; Taboada Antelo, Pablo (MDPI, 2021)
      Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics ...
    • Imprinted Contact Lenses for Ocular Administration of Antiviral Drugs 

      Varela García, Ángela; Gómez Amoza, José Luis; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2020)
      A variety of ocular diseases are caused by viruses, and most treatments rely on the use of systemic formulations and eye drops. The efficient ocular barriers that oppose antiviral drug penetration have prompted the development ...
    • Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins 

      Sobrinho, José Lamartine Soares; Soares, Mônica Felts de La Roca; Torres Labandeira, Santiago; Alves, Lariza Darlene Santos; Neto, Pedro José Rolim (Sociedade Brasileira de Química, 2011)
      This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were ...
    • Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool 

      Cabezas Sáinz, Pablo; Guerra Varela, Jorge; Carreira Nouche, María José; Mariscal Ávila, Javier; Roel Sánchez, María; Rubiolo Gaytán, Juan Andrés; Sciara, Andrés A.; Abal Posada, Miguel; Botana López, Luis Miguel; López López, Rafael; Sánchez Piñón, Laura Elena (Springer Nature, 2017)
      Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ...
    • In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation 

      Lorenzo Veiga, Blanca; Díaz Rodríguez, Patricia; Álvarez Lorenzo, Carmen Isabel; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI, 2020)
      The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in ...
    • In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin 

      Boente Juncal, Andrea; Raposo García, Sandra; Vale González, María del Carmen; Louzao Ojeda, María Carmen; Otero Fuertes, María Paz; Botana López, Luis Miguel (MDPI, 2020)
      Palytoxin (PLTX) is one of the most poisonous substances known to date and considered as an emergent toxin in Europe. Palytoxin binds to the Na+-K+ ATPase, converting the enzyme in a permeant cation channel. This toxin is ...
    • In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity 

      Raposo García, Sandra; Boente Juncal, Andrea; Camiña García, María Mercedes; Costas Sánchez, Celia; Cao-Cancelas, Alejandro; Louzao Ojeda, María Carmen; Cifuentes Martínez, José Manuel; Vale González, María del Carmen; Botana López, Luis Miguel; Rodriguez Vieytes, Mercedes (Springer, 2022)
      Ciguatoxins are marine compounds that share a ladder-shaped polyether structure produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa, and include maitotoxins (MTX1 and MTX3), ciguatoxins (CTX3C) and analogues ...
    • Influence of Different Shellfish Matrices on the Separation of PSP Toxins Using a Postcolumn Oxidation Liquid Chromatography Method 

      Rey López, Verónica; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Botana López, Ana María (MDPI, 2015)
      The separation of PSP toxins using liquid chromatography with a post-column oxidation fluorescence detection method was performed with different matrices. The separation of PSP toxins depends on several factors, and it is ...
    • Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation 

      Dunster, Joanne L.; Unsworth, Amanda J.; Bye, Alexander P.; Haining, Elizabeth J.; Sowa, Marcin A.; Di, Ying; Sage, Tanya; Pallin, Chiara; Pike, Jeremy A.; Hardy, Alexander T.; Nieswandt, Bernhard; García Alonso, Ángel; Watson, Steve P.; Poulter, Natalie S.; Gibbins, Jonathan M.; Pollitt, Alice Y. (Wiley, 2019)
      Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of subcellular ...
    • Intestinal secretory mechanisms in Okadaic acid induced diarrhoea 

      Costas Sánchez, Celia; Louzao Ojeda, María Carmen; Raposo García, Sandra; Vale González, María del Carmen; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (Elsevier, 2022)
      Okadaic acid (OA) is an important marine lipophilic phycotoxin responsible for diarrhetic shellfish poisoning (DSP). This toxin inhibits protein phosphatases (PPs) like PP2A and PP1, though, this action does not explain ...
    • Ionic and Polyampholyte N-Isopropylacrylamide-Based Hydrogels Prepared in the Presence of Imprinting Ligands: Stimuli-Responsiveness and Adsorption/Release Properties 

      Lago Crespo, Miguel Ángel; Grinberg, Valerij Ya; Burova, Tatiana V.; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2011)
      The conformation of the imprinted pockets in stimulus-responsive networks can be notably altered when the stimulus causes a volume phase transition. Such a tunable affinity for the template molecule finds interesting ...
    • Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin 

      López Iglesias, Clara; Barros, Joana; Ardao Palacios, Inés; Gurikov, Pavel; Monteiro, Fernando J.; Smirnova, Irina; Álvarez Lorenzo, Carmen Isabel; García González, Carlos Alberto (MDPI, 2020)
      Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of ...
    • Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery 

      Varela Fernández, Rubén; García Otero, Xurxo; Díaz Tomé, Victoria; Regueiro Lorenzo, Uxía; López López, María Teresa; González Barcia, Miguel; Lema Gesto, María Isabel; Otero Espinar, Francisco Javier (Elsevier, 2022)
      Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the ...
    • LC–MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels 

      Otero Fuertes, María Paz; Miguéns Gómez, Natalia; Rodríguez Filgueiras, Inés; Botana López, Luis Miguel (MDPI, 2019)
      The occurrence of marine harmful algae is increasing worldwide and, therefore, the accumulation of lipophilic marine toxins from harmful phytoplankton represents a food safety threat in the shellfish industry. Galicia, ...
    • Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications 

      López Iglesias, Clara; Quílez, Cristina; Barros, Joana; Velasco, Diego; Álvarez Lorenzo, Carmen Isabel; Jorcano, José L.; Monteiro, Fernando J.; García González, Carlos Alberto (MDPI, 2020)
      The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) ...





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