Now showing items 149-168 of 223

    • Paralytic Shellfish Toxins Occurrence in Non-Traditional Invertebrate Vectors from North Atlantic Waters (Azores, Madeira, and Morocco) 

      Silva, Marisa; Rey López, Verónica; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Botana López, Ana María; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2018)
      Paralytic shellfish toxins (PSTs) are potent alkaloids of microalgal and cyanobacterial origin, with worldwide distribution. Over the last 20 years, the number of poisoning incidents has declined as a result of the ...
    • Perimeter and carvacrol-loading regulate angiogenesis and biofilm growth in 3D printed PLA scaffolds 

      Farto Vaamonde, Xián; Díaz Gómez, Luis Antonio; Parga Martínez, Ana; Casal Otero, Ana María; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (Elsevier, 2022)
      rvacrol is a natural low-cost compound derived from oregano which presents anti-bacterial properties against both Gram-positive and Gram-negative bacteria. In this work, carvacrol-loaded PLA scaffolds were fabricated by ...
    • PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model 

      García Otero, Xurxo; Mondelo García, Cristina; Bandín Vilar, Enrique; Gómez Lado, Noemí; Silva Rodríguez, Jesús; Rey Bretal, David; Otero Espinar, María Victoria; Adán Civera, Alfredo; González Barcia, Miguel; Fernández Ferreiro, Anxo; Aguiar Fernández, Pablo; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo (Elsevier, 2022)
    • Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration 

      García Quintanilla, Laura; Luaces Rodríguez, Andrea; Gil Martínez, María; Mondelo García, Cristina; Maroñas Amigo, Olalla; Mangas Sanjuán, Víctor; González Barcia, Miguel; Zarra Ferro, Irene; Aguiar Fernández, Pablo; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo (MDPI, 2019)
      Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. ...
    • Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity 

      González Rodríguez, María; Ruiz Fernández, Clara; Vera, Francisco; Ait Eldjoudi, Djedjiga; Ramadan Farrag Abdel Hafez, Yousof; Cordero Barreal, Alfonso; Pino Mínguez, Jesús; Lago Paz, María Francisca; Campos Toimil, Manuel; Carvalho, Glaucimeire Rocha; Pereira, Thiago Melo Costa; Gualillo, Oreste (MDPI, 2021)
      Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk ...
    • Pluronic®/casein micelles for ophthalmic delivery of resveratrol: in vitro, ex vivo, and in vivo tests 

      Vivero López, María; Sparacino, Chiara; Quelle Regaldie, Ana; Sánchez Piñón, Laura Elena; Candal Suárez, Eva María; Barreiro Iglesias, Antón; Huete Toral, Fernando; Carracedo Rodríguez, Juan Gonzalo (Elsevier, 2022)
      Ocular health may strongly benefit from the supply of antioxidant agents that counteract free radicals and reactive oxygen species responsible for long-term eye diseases. Additionally, natural antioxidants like resveratrol ...
    • A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach 

      Vicente Ozores, Sara; Díaz Freitas, Belén; Peleteiro Olmedo, Mercedes; Sánchez Barreiro, Alejandro; Pascual, David W.; González Fernández, África; Alonso Fernández, María José (PLOS, 2013)
      The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting ...
    • Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System 

      Peleteiro Olmedo, Mercedes; Presas, Elena; González Aramundiz, José Vicente; Sánchez Correa, Beatriz; Simón Vázquez, Rosana; Csaba, Noemi Stefania; Alonso Fernández, María José; González Fernández, África (Frontiers Media, 2018)
      The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions ...
    • Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir 

      Donato, Cristina di; Iacovino, Rosa; Isernia, Carla; Malgieri, Gaetano; Varela García, Ángela; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2020)
      Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits ...
    • Polysaccharide nanoparticles can efficiently modulate the immune response against anHIV peptide antigen 

      Gómez Dacoba, Tamara; Omange, Robert W.; Li, Hongzhao; Crecente Campo, José; Luo, Ma; Alonso Fernández, María José (American Chemical Society, 2019)
      The development of an effective HIV vaccine continues to be a major health challenge since, so far, only the RV144 trial has demonstrated a modest clinical efficacy. Recently, the targeting of the 12 highly conserved ...
    • Polysaccharide-based aerogel microspheres for oral drug delivery 

      García González, Carlos Alberto; Jin, Ming; Gerth, J.; Álvarez Lorenzo, Carmen Isabel; Smirnova, I. (Elsevier, 2015-03-06)
      Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides ...
    • Polyurethanes as new excipients in nail therapeutics 

      Gregorí Valdes, Barbara S.; Serro, Ana Paula; Marto, Joana; Santos, Rui Galhano dos; Cutrín Gómez, Elena; Otero Espinar, Francisco Javier; Bordado, João Moura; Ribeiro, Helena Margarida (MDPI, 2018)
      Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually ...
    • Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives 

      Matos, Maria João Correia Pinto Carvalho de; Rodríguez Enríquez, Fernanda; Vilar, Santiago; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Hripcsak, George; Estrada, Martín; Rodríguez Franco, María Isabel; Viña Castelao, María Dolores (Elsevier, 2015)
      In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B ...
    • Potent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina 

      Amin, Surriya; Ullah, Barkat; Ali, Mumtaz; Rauf, Abdur; Khan, Haroon; Uriarte Villares, Eugenio; Sobarzo Sánchez, Eduardo Marcelo (MDPI, 2019)
      α-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial ...
    • Preclinical PET Study of Intravitreal Injections 

      Fernández Ferreiro, Anxo; Luaces Rodríguez, Andrea; Aguiar Fernández, Pablo; Pardo Montero, Juan; González Barcia, Miguel; García Varela, Lara; Herranz, Michel; Silva Rodríguez, Jesús; Gil Martínez, María; Bermúdez Vázquez, María Elvira; Vieites Prado, Alba; Blanco Méndez, José; Lamas Díaz, María Jesús; Gómez-Ulla de Irazazábal, Francisco Javier; Ruibal Morell, Álvaro; Otero Espinar, Francisco Javier; González García, Francisco (The Association for Research in Vision and Ophthalmology, 2017)
      PURPOSE. This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. METHODS. ...
    • Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates 

      Romero Durán, Francisco Javier; Alonso Sousa, Nerea; Caamaño Santos, María Olga; García Mera, Xerardo Xusto; Yañez Jato, Matilde; Prado Prado, Francisco Javier; González Díaz, Humberto (MDPI, 2014)
      In a multi-target complex network, the links (Lij) represent the interactions between the drug (di) and the target (tj), characterized by different experimental measures (Ki, Km, IC50, etc.) obtained in pharmacological ...
    • Prediction of Neurological Enzyme Targets for Known and New Compounds with a Model using Galvez's Topological Indices 

      Prado Prado, Francisco Javier; González Díaz, Humberto; Sobarzo Sánchez, Eduardo Marcelo; García Pintos, Isela (MDPI, 2015)
      Alzheimer's Disease (AD), Parkinson, and other neurodegenerative diseases are a major health problem nowadays. In this sense, the discovery of new drugs for neurodiseases treatment is a goal of the major importance. Public ...
    • Probiotics as beneficial dietary supplements to prevent and treat cardiovascular diseases: uncovering their impact on oxidative stress 

      Vasquez, Elisardo C.; Pereira, Thiago M.C.; Peotta, Veronica A.; Baldo, Marcelo P.; Campos Toimil, Manuel (Hindawi, 2019)
      The gut microbiota, the ecosystem formed by a wide symbiotic community of nonpathogenic microorganisms that are present in the distal part of the human gut, plays a prominent role in the normal physiology of the organism. ...
    • Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays 

      Salas, Cristian O.; Zarate, Ana Maria; Kryštof, Vladimir; Mella, Jaime; Faundez, Mario; Brea, José Manuel; Loza García, María Isabel; Brito, Ivan; Hendrychová, Denisa; Jorda, Radek; Cabrera, Alan R.; Tapia, Ricardo A.; Espinosa Bustos, Christian (MDPI, 2020)
      We designed, synthesized, and evaluated novel 2,6,9-trisubstituted purine derivatives for their prospective role as antitumor compounds. Using simple and efficient methodologies, 31 compounds were obtained. We tested these ...
    • Protective effects of kefir in the angiotensin II-dependent hypertension 

      Monteiro, Brenna Lepaus; Dias, Ananda Tissianel; Wanderkoke, Sthephany C.; Yokota, Rodrigo; Casarini, Dulce Elena; Leal, Marcos André Soares; Nogueira, Breno Valentim; Meyrelles, Silvana Santos; Campos Toimil, Manuel; Prandi Campagnaro, Bianca; Campos, Ruy Ribeiro; Pereira, Thiago Melo Costa; Vasquez, Elisardo Corral (Elsevier, 2020)
      Recently, we have reported cardiovascular protective effects of the probiotic kefir in a model of primary hypertension. Now, we evaluated the beneficial effects of kefir in a model of secondary hypertension under hyperactivation ...





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