Now showing items 1-20 of 217

    • 3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing 

      Díaz Gómez, Luis Antonio; González Prada, Iago; Millán Lence, Rosendo; Silva Candal, Andrés da; Bugallo Casal, Ana; Campos Pérez, Francisco; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (Elsevier, 2022)
      This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein ...
    • 3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology 

      Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2019)
      [ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the ...
    • 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients 

      Awad, Atheer; Yao, Aliya; Trenfield, Sarah J.; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W. (MDPI, 2020)
      Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating ...
    • 3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease 

      Seoane Viaño, Iria; Gómez Lado, Noemí; Lázare Iglesias, Héctor; García Otero, Xurxo; Antúnez López, José Ramón; Ruibal Morell, Álvaro; Varela Correa, Juan Jesús; Aguiar Fernández, Pablo; Basit, Abdul W.; Otero Espinar, Francisco Javier; González Barcia, Miguel; Goyanes Goyanes, Álvaro; Luzardo Álvarez, Asteria María; Fernández Ferreiro, Anxo (MDPI, 2020)
      The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel ...
    • 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method 

      Robles Martínez, Pamela; Xu, Xiaoyan; Trenfield, Sarah J.; Awad, Atheer; Goyanes Goyanes, Álvaro; Telford, Richard; Basit, Abdul W.; Gaisford, Simon (MDPI, 2019)
      Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise ...
    • 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering 

      Iglesias Mejuto, Ana; García González, Carlos Alberto (Elsevier, 2021)
      3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...
    • 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects 

      Pilar Olaya, María del; Vergel, Nadezdha Esperanza; López, Jose Luis; Viña Castelao, María Dolores (Universidade de São Paulo, 2020)
      Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new ...
    • Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX 

      Fernández Ferreiro, Sara; Carrera González, María Cristina; Vilariño del Río, Natalia; Louzao Ojeda, María Carmen; Santamarina Pernas, Germán; González Cantalapiedra, Antonio; Botana López, Luis Miguel (MDPI, 2015)
      Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins ...
    • Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods ...
    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • Aerogels as porous structures for food applications: Smart ingredients and novel packaging materials 

      Manzocco, Lara; Mikkonen, Kirsi S.; García González, Carlos Alberto (Elsevier, 2021)
      Aerogels are nanostructured materials with low density, high surface area (>150 m2/g) and open porosity (typically 95–99.99 %). They are obtained by solvent removal from gels while preserving network structure. Hydrogels, ...
    • Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens 

      Chahal, Rubal; Nanda, Arun; Küpeli Akkol, Esra; Sobarzo Sánchez, Eduardo Marcelo; Arya, Ashwani; Kaushik, Deepak; Dutt, Rohit; Bhardwaj, Rashmi; Rahman, Md. Habibur; Mittal, Vineet (MDPI, 2021)
      Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including ...
    • An Opinion Paper on Aerogels for Biomedical and Environmental Applications 

      García González, Carlos Alberto; Budtova, Tatiana; Duräes, Luisa; Erkey, Can; Gaudio, Pasquale del; Gurikov, Pavel; Koebel, Matthias; Liebner, Falk; Neagu, Monica; Smirnova, Irina (MDPI, 2019)
      Aerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Although a few types of aerogels have already reached the market in construction materials, textiles ...
    • Anhydroexfoliamycin, a Streptomyces Secondary Metabolite, Mitigates Microglia-Driven Inflammation 

      Gegunde Mosquera, Sandra; Alfonso Rancaño, María Amparo; Alvariño Romero, Rebeca; Pérez Fuentes, Nadia; Botana López, Luis Miguel (ACS Publications, 2021)
      Anhydroexfoliamycin, a secondary metabolite from Streptomyces, has shown antioxidant properties in primary cortical neurons reducing neurodegenerative hallmarks diseases, both in vitro and in vivo models. Activated microglia, ...
    • Antioxidant and neuroprotective potential of the Brown Seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model 

      Silva, Joana M.; Alves, Celso; Freitas, Rafaela; Martins, Alice; Pinteus, Susete; Ribeiro, Joana; Gaspar, Helena; Alfonso Rancaño, María Amparo; Pedrosa, Rui (MDPI, 2019)
      Bifurcaria bifurcata is a marine brown seaweed mainly found on the Atlantic coast. Herein, we report the antioxidant and neuroprotective activities of seven fractions (F1–F7) obtained by normal phase chromatography from ...
    • Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications 

      Domínguez Robles, Juan; Martin, Niamh K.; Fong, Mun Leon; Stewart, Sarah A.; Irwin, Nicola J.; Rial Hermida, María Isabel; Donnelly, Ryan F.; Larrañeta, Eneko (MDPI, 2019)
      Lignin (LIG) is a natural biopolymer with well-known antioxidant capabilities. Accordingly, in the present work, a method to combine LIG with poly(lactic acid) (PLA) for fused filament fabrication applications (FFF) is ...
    • Artificial intelligence applied to flavonoid data in food matrices 

      Guardado Yordi, Estela; Koelig, Raúl; Matos, Maria João Correia Pinto Carvalho de; Pérez Martínez, Amaury; Caballero, Yailé; Santana Penín, María Lourdes; Pérez Quintana, Manuel; Molina, Enrique; Uriarte Villares, Eugenio (MDPI, 2019)
      Increasing interest in constituents and dietary supplements has created the need for more efficient use of this information in nutrition-related fields. The present work aims to obtain optimal models to predict the total ...
    • Asymmetry in Drug Permeability through the Cornea 

      Toffoletto, Nadia; Chauhan, Anuj; Álvarez Lorenzo, Carmen Isabel; Saramago, Benilde; Serro, Ana Paula (MDPI, 2021)
      The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained ...
    • Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release 

      Pereira da Mota, Ana Filipa; Vivero López, María; Topete, Ana; Serro, Ana Paula; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2021)
      Statins are receiving increasing attention in the ophthalmic field. Their activity as 3-hydroxy-3-methylglutaryl–CoA (HMG–CoA) reductase inhibitors is clinically used to regulate cholesterol levels and leads to pleiotropic ...





      Harvesters:Useful links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback