Now showing items 9-28 of 217

    • Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX 

      Fernández Ferreiro, Sara; Carrera González, María Cristina; Vilariño del Río, Natalia; Louzao Ojeda, María Carmen; Santamarina Pernas, Germán; González Cantalapiedra, Antonio; Botana López, Luis Miguel (MDPI, 2015)
      Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins ...
    • Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2019)
      Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods ...
    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • Aerogels as porous structures for food applications: Smart ingredients and novel packaging materials 

      Manzocco, Lara; Mikkonen, Kirsi S.; García González, Carlos Alberto (Elsevier, 2021)
      Aerogels are nanostructured materials with low density, high surface area (>150 m2/g) and open porosity (typically 95–99.99 %). They are obtained by solvent removal from gels while preserving network structure. Hydrogels, ...
    • Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens 

      Chahal, Rubal; Nanda, Arun; Küpeli Akkol, Esra; Sobarzo Sánchez, Eduardo Marcelo; Arya, Ashwani; Kaushik, Deepak; Dutt, Rohit; Bhardwaj, Rashmi; Rahman, Md. Habibur; Mittal, Vineet (MDPI, 2021)
      Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including ...
    • An Opinion Paper on Aerogels for Biomedical and Environmental Applications 

      García González, Carlos Alberto; Budtova, Tatiana; Duräes, Luisa; Erkey, Can; Gaudio, Pasquale del; Gurikov, Pavel; Koebel, Matthias; Liebner, Falk; Neagu, Monica; Smirnova, Irina (MDPI, 2019)
      Aerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Although a few types of aerogels have already reached the market in construction materials, textiles ...
    • Anhydroexfoliamycin, a Streptomyces Secondary Metabolite, Mitigates Microglia-Driven Inflammation 

      Gegunde Mosquera, Sandra; Alfonso Rancaño, María Amparo; Alvariño Romero, Rebeca; Pérez Fuentes, Nadia; Botana López, Luis Miguel (ACS Publications, 2021)
      Anhydroexfoliamycin, a secondary metabolite from Streptomyces, has shown antioxidant properties in primary cortical neurons reducing neurodegenerative hallmarks diseases, both in vitro and in vivo models. Activated microglia, ...
    • Antioxidant and neuroprotective potential of the Brown Seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model 

      Silva, Joana M.; Alves, Celso; Freitas, Rafaela; Martins, Alice; Pinteus, Susete; Ribeiro, Joana; Gaspar, Helena; Alfonso Rancaño, María Amparo; Pedrosa, Rui (MDPI, 2019)
      Bifurcaria bifurcata is a marine brown seaweed mainly found on the Atlantic coast. Herein, we report the antioxidant and neuroprotective activities of seven fractions (F1–F7) obtained by normal phase chromatography from ...
    • Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications 

      Domínguez Robles, Juan; Martin, Niamh K.; Fong, Mun Leon; Stewart, Sarah A.; Irwin, Nicola J.; Rial Hermida, María Isabel; Donnelly, Ryan F.; Larrañeta, Eneko (MDPI, 2019)
      Lignin (LIG) is a natural biopolymer with well-known antioxidant capabilities. Accordingly, in the present work, a method to combine LIG with poly(lactic acid) (PLA) for fused filament fabrication applications (FFF) is ...
    • Artificial intelligence applied to flavonoid data in food matrices 

      Guardado Yordi, Estela; Koelig, Raúl; Matos, Maria João Correia Pinto Carvalho de; Pérez Martínez, Amaury; Caballero, Yailé; Santana Penín, María Lourdes; Pérez Quintana, Manuel; Molina, Enrique; Uriarte Villares, Eugenio (MDPI, 2019)
      Increasing interest in constituents and dietary supplements has created the need for more efficient use of this information in nutrition-related fields. The present work aims to obtain optimal models to predict the total ...
    • Asymmetry in Drug Permeability through the Cornea 

      Toffoletto, Nadia; Chauhan, Anuj; Álvarez Lorenzo, Carmen Isabel; Saramago, Benilde; Serro, Ana Paula (MDPI, 2021)
      The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained ...
    • Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release 

      Pereira da Mota, Ana Filipa; Vivero López, María; Topete, Ana; Serro, Ana Paula; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2021)
      Statins are receiving increasing attention in the ophthalmic field. Their activity as 3-hydroxy-3-methylglutaryl–CoA (HMG–CoA) reductase inhibitors is clinically used to regulate cholesterol levels and leads to pleiotropic ...
    • Benzopyran-2-ones as attractive scaffold for MAO inhibitors: synthesis, biological evaluation and docking studies 

      Vázquez Rodríguez, Saleta; Matos, Maria João Correia Pinto Carvalho de; Uriarte Villares, Eugenio; Ferino, Giulio; Cadoni, Enzo; Viña Castelao, María Dolores (MDPI, 2011)
      Neurodegenerative diseases are becoming prevalent pathologies in developed societies due to increasing average of life expectancy of the population. This fact has encouraged an active research in the development of new ...
    • Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds 

      Bernardes, Beatriz; Gaudio, Pasquale del; Alves, Paulo; Costa, Raquel; García González, Carlos Alberto; Oliveira, Ana (MDPI, 2021)
      Wounds affect one’s quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards ...
    • Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells 

      Alvariño Romero, Rebeca; Alonso López, Eva; Bornancin, Louis; Bonnard, Isabelle; Inguimbert, Nicolas; Banaigs, Bernard; Botana López, Luis Miguel (MDPI, 2020)
      Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. ...
    • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery 

      Mazet, Roseline; García Otero, Xurxo; Choisnard, Luc; Wouessidjewe, Denis; Verdoot, Vincent; Bossard, Frédéric; Díaz Tomé, Victoria; Blanc Marquis, Véronique; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo; Gèze, Annabelle (MDPI, 2020)
      We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD ...
    • Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia 

      Pérez Mato, María; Iglesias Rey, Ramón; Vieites Prado, Alba; Dopico López, Antonio; Argibay González, Bárbara; Fernández Susavila, Héctor; Silva Candal, Andrés da; Pérez Díaz, Amparo; Correa Paz, Clara; Günther, Anne; Ávila Gómez, Paulo; Loza García, María Isabel; Baumann, Arnd; Castillo Sánchez, José Antonio; Sobrino Moreiras, Tomás; Campos Pérez, Francisco (Elsevier, 2019-01)
      Background Excitatory amino acid transporter 2 (EAAT2) plays a pivotal role in glutamate clearance in the adult brain, thereby preventing excitotoxic effects. Considering the high efficacy of EAAT2 for glutamate uptake, ...
    • Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra 

      Miguel Gordo, María; Gegunde Mosquera, Sandra; Calabro, Kevin; Jennings, Laurence K.; Alfonso Rancaño, María Amparo; Genta-Jouve, Grégory; Vacelet, Jean; Botana López, Luis Miguel; Thomas, Olivier P. (MDPI, 2019)
      So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first ...
    • Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA 

      Álvarez González, José Víctor; Bravo López, Susana Belén; Chantada Vázquez, María del Pilar; Colón Mejeras, Cristóbal; Castro López, María José de; Morales, Montserrat; Vitoria, Isidro; Tomatsu, Shunji; Otero Espinar, Francisco Javier; Couce Pico, María de la Luz (MDPI, 2021)
      Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused ...
    • Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation 

      Sánchez Sánchez, María Pilar; Martín Illana, Araceli; Ruiz Caro, Roberto; Bermejo, Paulina; Abad, María José; Carro, Rubén; Bedoya, Luis Miguel; Tamayo, Aitana; Rubio, Juan; Fernández Ferreiro, Anxo; Otero Espinar, Francisco Javier; Veiga, María Dolores (MDPI, 2015)
      Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Polysaccharides, such as chitosan and carrageenan, which have good binding capacity with ...





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