Now showing items 85-104 of 217

    • Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands 

      Rataj, Krzysztof; Andor Kelemen, Ádám; Brea Floriani, José Manuel; Loza García, María Isabel; Bojarski, Andrzej J.; Keserű, György Miklós (MDPI, 2018)
      The identification of subtype-selective GPCR (G-protein coupled receptor) ligands is a challenging task. In this study, we developed a computational protocol to find compounds with 5-HT2BR versus 5-HT1BR selectivity. Our ...
    • First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum 

      Vlamis, Aristidis; Katikou, Panagiota; Rodríguez Filgueiras, Inés; Rey López, Verónica; Alfonso Rancaño, María Amparo; Papazachariou, Angelos; Zacharaki, Thetis; Botana López, Ana María; Botana López, Luis Miguel (MDPI, 2015)
      During official shellfish control for the presence of marine biotoxins in Greece in year 2012, a series of unexplained positive mouse bioassays (MBA) for lipophilic toxins with nervous symptomatology prior to mice death ...
    • First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis 

      Silva, Marisa; Rodríguez Filgueiras, Inés; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2015)
      Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). These phycotoxins are produced mainly by dinoflagellates that belong to the genus Gambierdiscus that are ...
    • From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp. 

      García Pérez, Pascual; Lozano Milo, Eva; Landín Pérez, Mariana; Gallego, Pedro Pablo (MDPI, 2020)
      The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ...
    • Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging 

      Gómez Lado, Noemí; Seoane Viaño, Iria; Matiz, Silvia; Madla, Christine M.; Yadav, Vipul; Aguiar Fernández, Pablo; Basit, Abdul W.; Goyanes Goyanes, Álvaro (MDPI, 2020)
      Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal ...
    • Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin 

      Ruiz DeDiego, Irene; Fasano, Stefania; Solís, Oscar; Garcia Montes, José Rubén; Brea Floriani, José Manuel; Loza García, María Isabel; Brambilla, Riccardo; Moratalla, Rosario (Nature Publishing Group, 2018)
      Increasing evidence supports a close relationship between Ras-ERK1/2 activation in the striatum and L-DOPA-induced dyskinesia (LID). ERK1/2 activation by L-DOPA takes place through the crosstalk between D1R/AC/PKA/DARPP-32 ...
    • Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro 

      Núñez Iglesias, María Jesús; Novío Mallón, Silvia; García Santiago, Carlota; Pérez Muñuzuri, Elena; Soengas Fernández, María del Pilar; Cartea González, María Elena; Velasco Pazos, Pablo; Freire-Garabal Núñez, Manuel (MDPI, 2019)
      Glucosinolate-degradation products (GS-degradation products) are believed to be responsible for the anticancer effects of cruciferous vegetables. Furthermore, they could improve the efficacy and reduce side-effects of ...
    • GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity 

      Núñez Barrachina, María; Sueiro, Aurelio M.; Izquierdo Berjano, Irene; Hermida Nogueira, Lidia; Guitián Fernández, Esteban; Casanueva Freijo, Felipe; Farndale, Richard W.; Masaaki, Moroi; Jung, Stephanie M.; Pardo Pérez, María; García Alonso, Ángel (Elsevier, 2019)
      Background and aims: Platelets play a fundamental role in the increased atherothrombotic risk related to central obesity since they show hyperactivation and lower sensitivity to antiplatelet therapy in obese patients. The ...
    • Gut microbiota, diet, and chronic diseases: the role played by oxidative stress 

      Vasquez, Elisardo C.; Pereira, Thiago M.C.; Campos Toimil, Manuel; Baldo, Marcelo P.; Peotta, Veronica A. (Hindawi, 2019)
    • Heart Alterations after Domoic Acid Administration in Rats 

      Crespo Vieira, Andrés; Cifuentes Martínez, José Manuel; Bermúdez Pose, Roberto; Fernández Ferreiro, Sara; Román Castro, Albina; Botana López, Luis Miguel (MDPI AG, 2016-03-10)
      Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries ...
    • Hesperidin as a neuroprotective agent: a review of animal and clinical evidence 

      Hajialyani, Marziyeh; Farzaei, Mohammad Hosein; Echeverría, Javier; Nabavi, Seyed Mohammad; Uriarte Villares, Eugenio; Sobarzo Sánchez, Eduardo Marcelo (MDPI, 2019)
      Neuroprotection is the preservation of function and networks of neural tissues from damages caused by various agents, as well as neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Huntington’s diseases, and ...
    • High serum cyclophilin C levels as a risk factor marker for coronary artery disease 

      Alfonso Rancaño, María Amparo; Bayón Lorenzo, Jeremías; Gegunde Mosquera, Sandra; Alonso López, Eva; Alvariño Romero, Rebeca; Santás Álvarez, Melisa; Testa Fernández, Ana; Ríos Vázquez, Ramón; González Juanatey, Carlos; Botana López, Luis Miguel (Nature Publishing Group, 2019)
      Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with infammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are ...
    • How Safe Is Safe for Marine Toxins Monitoring? 

      Botana López, Luis Miguel; Alfonso Rancaño, María Amparo; Rodríguez Filgueiras, Inés; Botana López, Ana María; Louzao Ojeda, María Carmen; Rodríguez Vieytes, María Mercedes (MDPI AG, 2016-07-06)
      Current regulation for marine toxins requires a monitoring method based on mass spectrometric analysis. This method is pre-targeted, hence after searching for pre-assigned masses, it identifies those compounds that were ...
    • Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing 

      Amato, Giovanni; Grimaudo, Maria Aurora; Álvarez Lorenzo, Carmen Isabel; Concheiro Nine, Ángel Joaquín; Carbone, Claudia; Bonaccorso, Angela; Puglisi, Giovanni; Musumeci, Teresa (MDPI, 2021)
      Physiological wound healing process can be delayed in the presence of certain pathologies, such as diabetes or cancer. In this perspective, the aim of this study was to design a new nanogel platform of hyaluronan, poly-L-lysine ...
    • Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications 

      Velasco Rodríguez, Brenda; Diaz Vidal, Tania; Rosales Rivera, Luis Carlos; García González, Carlos Alberto; Álvarez Lorenzo, Carmen Isabel; Al-Modlej, Abeer; Domínguez Arca, Vicente; Prieto Estévez, Gerardo; Barbosa Fernández, Silvia; Soltero Martinez, José Félix Armando; Taboada Antelo, Pablo (MDPI, 2021)
      Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics ...
    • Imprinted Contact Lenses for Ocular Administration of Antiviral Drugs 

      Varela García, Ángela; Gómez Amoza, José Luis; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2020)
      A variety of ocular diseases are caused by viruses, and most treatments rely on the use of systemic formulations and eye drops. The efficient ocular barriers that oppose antiviral drug penetration have prompted the development ...
    • Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins 

      Sobrinho, José Lamartine Soares; Soares, Mônica Felts de La Roca; Torres Labandeira, Santiago; Alves, Lariza Darlene Santos; Neto, Pedro José Rolim (Sociedade Brasileira de Química, 2011)
      This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were ...
    • Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool 

      Cabezas Sáinz, Pablo; Guerra Varela, Jorge; Carreira Nouche, María José; Mariscal Ávila, Javier; Roel Sánchez, María; Rubiolo Gaytán, Juan Andrés; Sciara, Andrés A.; Abal Posada, Miguel; Botana López, Luis Miguel; López López, Rafael; Sánchez Piñón, Laura Elena (Springer Nature, 2017)
      Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ...
    • In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation 

      Lorenzo Veiga, Blanca; Díaz Rodríguez, Patricia; Álvarez Lorenzo, Carmen Isabel; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI, 2020)
      The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in ...
    • In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin 

      Boente Juncal, Andrea; Raposo García, Sandra; Vale González, María del Carmen; Louzao Ojeda, María Carmen; Otero Fuertes, María Paz; Botana López, Luis Miguel (MDPI, 2020)
      Palytoxin (PLTX) is one of the most poisonous substances known to date and considered as an emergent toxin in Europe. Palytoxin binds to the Na+-K+ ATPase, converting the enzyme in a permeant cation channel. This toxin is ...





      Harvesters:Useful links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback