Now showing items 141-160 of 217

    • Occurrence of mycotoxins and mycotoxigenic fungi in silage from the north of Portugal at feed-out 

      González Jartín, Jesús María; Ferreiroa Martínez, Vanesa; Rodríguez Cañás, Inés; Alfonso Rancaño, María Amparo; Sainz Osés, María Jesús; Aguín Casal, Olga María; Rodríguez Vieytes, María Mercedes; Gomes, Ana; Ramos, Isabel; Botana López, Luis Miguel (Elsevier, 2022)
      Maize and grass silages are important dietary components for ruminant livestock that influence the quality of animal products for human consumption, such as milk, in many parts of the world. Infection of plants by fungi ...
    • Ocular biodistribution studies using molecular imaging 

      Castro Balado, Ana; Mondelo García, Cristina; González Barcia, Miguel; Zarra Ferro, Irene; Otero Espinar, Francisco Javier; Ruibal Morell, Álvaro; Aguiar Fernández, Pablo; Fernández Ferreiro, Anxo (MDPI, 2019)
      Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple ...
    • Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers 

      Cutrín Gómez, Elena; Conde Penedo, Andrea; Anguiano Igea, Soledad; Gómez Amoza, José Luis; Otero Espinar, Francisco Javier (MDPI, 2020)
      Cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers have demonstrated significant capacity for promoting the permeation of drugs into the nail plate. Furthermore, previous studies have shown that the use ...
    • Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin 

      Boente Juncal, Andrea; Otero Fuertes, María Paz; Rodríguez Filgueiras, Inés; Camiña García, María Mercedes; Rodríguez Vieytes, María Mercedes; Vale González, María del Carmen; Botana López, Luis Miguel (MDPI, 2020)
      Tetrodotoxin (TTX) is a potent natural toxin causative of human food intoxications that shares its mechanism of action with the paralytic shellfish toxin saxitoxin (STX). Both toxins act as potent blockers of voltage-gated ...
    • Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression 

      Crespo Vieira, Andrés; Rubiolo Gaytán, Juan Andrés; López Alonso, Henar; Cifuentes Martínez, José Manuel; Alfonso Rancaño, María Amparo; Bermúdez Pose, Roberto; Otero Fuertes, María Paz; Rodríguez Vieytes, María Mercedes; Vega Lisi, Félix Víctor; Botana López, Luis Miguel (MDPI, 2013)
      In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different ...
    • Oxidative Stress and Dementia in Alzheimer’s Patients: Effects of Synbiotic Supplementation 

      Mendonça Marques Ton, Alyne; Prandi Campagnaro, Bianca; Aleixo Alves, Gisela; Aires, Rafaela; Zambom Côco, Larissa; Maximo Arpini, Clarisse; Guerra e Oliveira, Trícia; Campos Toimil, Manuel; Santos Meyrelles, Silvana; Melo Costa Pereira, Thiago; Corral Vasquez, Elisardo (Hindawi, 2020)
      Alzheimer’s disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. ...
    • Paralytic Shellfish Toxins Occurrence in Non-Traditional Invertebrate Vectors from North Atlantic Waters (Azores, Madeira, and Morocco) 

      Silva, Marisa; Rey López, Verónica; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Botana López, Ana María; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2018)
      Paralytic shellfish toxins (PSTs) are potent alkaloids of microalgal and cyanobacterial origin, with worldwide distribution. Over the last 20 years, the number of poisoning incidents has declined as a result of the ...
    • Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration 

      García Quintanilla, Laura; Luaces Rodríguez, Andrea; Gil Martínez, María; Mondelo García, Cristina; Maroñas Amigo, Olalla; Mangas Sanjuán, Víctor; González Barcia, Miguel; Zarra Ferro, Irene; Aguiar Fernández, Pablo; Otero Espinar, Francisco Javier; Fernández Ferreiro, Anxo (MDPI, 2019)
      Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. ...
    • Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity 

      González Rodríguez, María; Ruiz Fernández, Clara; Vera, Francisco; Ait Eldjoudi, Djedjiga; Ramadan Farrag Abdel Hafez, Yousof; Cordero Barreal, Alfonso; Pino Mínguez, Jesús; Lago Paz, María Francisca; Campos Toimil, Manuel; Carvalho, Glaucimeire Rocha; Pereira, Thiago Melo Costa; Gualillo, Oreste (MDPI, 2021)
      Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk ...
    • A Polymer/Oil Based Nanovaccine as a Single-Dose Immunization Approach 

      Vicente Ozores, Sara; Díaz Freitas, Belén; Peleteiro Olmedo, Mercedes; Sánchez Barreiro, Alejandro; Pascual, David W.; González Fernández, África; Alonso Fernández, María José (PLOS, 2013)
      The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting ...
    • Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System 

      Peleteiro Olmedo, Mercedes; Presas, Elena; González Aramundiz, José Vicente; Sánchez Correa, Beatriz; Simón Vázquez, Rosana; Csaba, Noemi Stefania; Alonso Fernández, María José; González Fernández, África (Frontiers Media, 2018)
      The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions ...
    • Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir 

      Donato, Cristina di; Iacovino, Rosa; Isernia, Carla; Malgieri, Gaetano; Varela García, Ángela; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel (MDPI, 2020)
      Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits ...
    • Polysaccharide nanoparticles can efficiently modulate the immune response against anHIV peptide antigen 

      Gómez Dacoba, Tamara; Omange, Robert W.; Li, Hongzhao; Crecente Campo, José; Luo, Ma; Alonso Fernández, María José (American Chemical Society, 2019)
      The development of an effective HIV vaccine continues to be a major health challenge since, so far, only the RV144 trial has demonstrated a modest clinical efficacy. Recently, the targeting of the 12 highly conserved ...
    • Polysaccharide-based aerogel microspheres for oral drug delivery 

      García González, Carlos Alberto; Jin, Ming; Gerth, J.; Álvarez Lorenzo, Carmen Isabel; Smirnova, I. (Elsevier, 2015-03-06)
      Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides ...
    • Polyurethanes as new excipients in nail therapeutics 

      Gregorí Valdes, Barbara S.; Serro, Ana Paula; Marto, Joana; Santos, Rui Galhano dos; Cutrín Gómez, Elena; Otero Espinar, Francisco Javier; Bordado, João Moura; Ribeiro, Helena Margarida (MDPI, 2018)
      Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually ...
    • Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives 

      Matos, Maria João Correia Pinto Carvalho de; Rodríguez Enríquez, Fernanda; Vilar, Santiago; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Hripcsak, George; Estrada, Martín; Rodríguez Franco, María Isabel; Viña Castelao, María Dolores (Elsevier, 2015)
      In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B ...
    • Potent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina 

      Amin, Surriya; Ullah, Barkat; Ali, Mumtaz; Rauf, Abdur; Khan, Haroon; Uriarte Villares, Eugenio; Sobarzo Sánchez, Eduardo Marcelo (MDPI, 2019)
      α-glucosidase is responsible for the hydrolysis of complex carbohydrates into simple absorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the ideal target to prevent postprandial ...
    • Preclinical PET Study of Intravitreal Injections 

      Fernández Ferreiro, Anxo; Luaces Rodríguez, Andrea; Aguiar Fernández, Pablo; Pardo Montero, Juan; González Barcia, Miguel; García Varela, Lara; Herranz, Michel; Silva Rodríguez, Jesús; Gil Martínez, María; Bermúdez Vázquez, María Elvira; Vieites Prado, Alba; Blanco Méndez, José; Lamas Díaz, María Jesús; Gómez-Ulla de Irazazábal, Francisco Javier; Ruibal Morell, Álvaro; Otero Espinar, Francisco Javier; González García, Francisco (The Association for Research in Vision and Ophthalmology, 2017)
      PURPOSE. This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. METHODS. ...
    • Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates 

      Romero Durán, Francisco Javier; Alonso Sousa, Nerea; Caamaño Santos, María Olga; García Mera, Xerardo Xusto; Yañez Jato, Matilde; Prado Prado, Francisco Javier; González Díaz, Humberto (MDPI, 2014)
      In a multi-target complex network, the links (Lij) represent the interactions between the drug (di) and the target (tj), characterized by different experimental measures (Ki, Km, IC50, etc.) obtained in pharmacological ...
    • Prediction of Neurological Enzyme Targets for Known and New Compounds with a Model using Galvez's Topological Indices 

      Prado Prado, Francisco Javier; González Díaz, Humberto; Sobarzo Sánchez, Eduardo Marcelo; García Pintos, Isela (MDPI, 2015)
      Alzheimer's Disease (AD), Parkinson, and other neurodegenerative diseases are a major health problem nowadays. In this sense, the discovery of new drugs for neurodiseases treatment is a goal of the major importance. Public ...





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