Now showing items 1-5 of 5

    • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

      Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
      Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
    • Engineering, on-demand manufacturing, and scaling-up ofpolymeric nanocapsules 

      Crecente Campo, José; Alonso Fernández, María José (Willey, 2019)
      Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System 

      Peleteiro Olmedo, Mercedes; Presas, Elena; González Aramundiz, José Vicente; Sánchez Correa, Beatriz; Simón Vázquez, Rosana; Csaba, Noemi Stefania; Alonso Fernández, María José; González Fernández, África (Frontiers Media, 2018)
      The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions ...
    • Quantification of the actual composition of polymeric nanocapsules: a quality control analysis 

      Berrecoso Cuña, Germán; Crecente Campo, José; Alonso Fernández, María José (Springer, 2022)
      Nanocapsules (NCs) are drug delivery nanosystems that contain an oily core, stabilized by a surfactant, and surrounded by a polymeric shell. The assembling of the components is based on physical and physicochemical forces, ...

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